MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000075785 RAB7A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.793814 View
ENSG00000123200 ZC3H13 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.792856 View
ENSG00000104852 SNRNP70 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.792803 View
ENSG00000068024 HDAC4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.79245 View
ENSG00000050748 MAPK9 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.791991 View
ENSG00000169032 MAP2K1 ENSG00000178999 AURKB H. sapiens SSL Slorth 0.791044 View
ENSG00000164032 H2AFZ ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.790167 View
ENSG00000169032 MAP2K1 ENSG00000178950 GAK H. sapiens SSL Slorth 0.789738 View
ENSG00000106245 BUD31 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.789634 View
ENSG00000169032 MAP2K1 ENSG00000170144 HNRNPA3 H. sapiens SSL Slorth 0.789295 View
ENSG00000095002 MSH2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.788337 View
ENSG00000169032 MAP2K1 ENSG00000170315 UBB H. sapiens SSL Slorth 0.787117 View
ENSG00000065427 KARS ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.786526 View
ENSG00000148606 POLR3A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.784883 View
ENSG00000105011 ASF1B ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.784125 View
ENSG00000101811 CSTF2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.783815 View
ENSG00000137076 TLN1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.783102 View
ENSG00000153250 RBMS1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.783078 View
ENSG00000047315 POLR2B ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.782917 View
ENSG00000101557 USP14 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.78246 View
ENSG00000160803 UBQLN4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.781877 View
ENSG00000141552 ANAPC11 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.781299 View
ENSG00000163558 PRKCI ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.77974 View
ENSG00000064995 TAF11 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.779131 View
ENSG00000135250 SRPK2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.776672 View
ENSG00000073584 SMARCE1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.775896 View
ENSG00000169032 MAP2K1 ENSG00000197122 SRC H. sapiens SSL Slorth 0.774068 View
ENSG00000116473 RAP1A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.773503 View
ENSG00000001167 NFYA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.772889 View
ENSG00000116288 PARK7 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.771782 View
ENSG00000169032 MAP2K1 ENSG00000198561 CTNND1 H. sapiens SSL Slorth 0.770233 View
ENSG00000116459 ATP5F1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.770093 View
ENSG00000169032 MAP2K1 ENSG00000175197 DDIT3 H. sapiens SSL Slorth 0.769082 View
ENSG00000169032 MAP2K1 ENSG00000198554 WDHD1 H. sapiens SSL Slorth 0.768546 View
ENSG00000053372 MRTO4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.768517 View
ENSG00000076242 MLH1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.768105 View
ENSG00000169032 MAP2K1 ENSG00000169813 HNRNPF H. sapiens SSL Slorth 0.767395 View
ENSG00000101460 MAP1LC3A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.766721 View
ENSG00000134602 STK26 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.765933 View
ENSG00000164362 TERT ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.764656 View