MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000168036 CTNNB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.819135 View
ENSG00000118689 FOXO3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.818948 View
ENSG00000067606 PRKCZ ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.818936 View
ENSG00000169032 MAP2K1 ENSG00000172936 MYD88 H. sapiens SSL Slorth 0.8173 View
ENSG00000094916 CBX5 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.8172 View
ENSG00000118503 TNFAIP3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.817173 View
ENSG00000106355 LSM5 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.815927 View
ENSG00000159216 RUNX1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.815728 View
ENSG00000117222 RBBP5 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.815453 View
ENSG00000157404 KIT ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.815294 View
ENSG00000080503 SMARCA2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.814519 View
ENSG00000107643 MAPK8 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.814144 View
ENSG00000139842 CUL4A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.814119 View
ENSG00000100028 SNRPD3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.812735 View
ENSG00000077097 TOP2B ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.811816 View
ENSG00000090372 STRN4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.810851 View
ENSG00000162298 SYVN1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.80983 View
ENSG00000124164 VAPB ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.808762 View
ENSG00000162367 TAL1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.808417 View
ENSG00000080986 NDC80 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.808224 View
ENSG00000128052 KDR ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.808022 View
ENSG00000169032 MAP2K1 ENSG00000254772 EEF1G H. sapiens SSL Slorth 0.807833 View
ENSG00000115816 CEBPZ ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.807747 View
ENSG00000166598 HSP90B1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.807029 View
ENSG00000071051 NCK2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.806335 View
ENSG00000104375 STK3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.80579 View
ENSG00000106299 WASL ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.805534 View
ENSG00000068078 FGFR3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.805211 View
ENSG00000051382 PIK3CB ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.803937 View
ENSG00000162236 STX5 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.803819 View
ENSG00000084774 CAD ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.803416 View
ENSG00000113013 HSPA9 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.802954 View
ENSG00000102572 STK24 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.80084 View
ENSG00000050820 BCAR1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.800806 View
ENSG00000115808 STRN ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.798486 View
ENSG00000163930 BAP1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.798268 View
ENSG00000158092 NCK1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.798025 View
ENSG00000092108 SCFD1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.797485 View
ENSG00000169032 MAP2K1 ENSG00000169083 AR H. sapiens SSL Slorth 0.795545 View
ENSG00000130699 TAF4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.794558 View