KIT

ENSG00000157404 - H. sapiens

Pathways

Go term Description
GO:0002020 protease binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0005020 stem cell factor receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019955 cytokine binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Drugs

Drug name Description
CABOZANTINIB
DASATINIB Tyrosine-protein kinase ABL inhibitor
IMATINIB Tyrosine-protein kinase ABL inhibitor
LENVATINIB
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
PONATINIB Tyrosine-protein kinase ABL inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
GIST
AML
TGCT
mastocytosis
mucosal melanoma
epithelioma

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000157404 KIT ENSG00000108443 RPS6KB1 H. sapiens SSL BioGRID 1.0 View
ENSG00000012048 BRCA1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.986077 View
ENSG00000142208 AKT1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.984774 View
ENSG00000091831 ESR1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.983046 View
ENSG00000150991 UBC ENSG00000157404 KIT H. sapiens SDL Slorth 0.982662 View
ENSG00000146648 EGFR ENSG00000157404 KIT H. sapiens SDL Slorth 0.980486 View
ENSG00000100393 EP300 ENSG00000157404 KIT H. sapiens SDL Slorth 0.980095 View
ENSG00000005339 CREBBP ENSG00000157404 KIT H. sapiens SDL Slorth 0.979351 View
ENSG00000080824 HSP90AA1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.97891 View
ENSG00000109670 FBXW7 ENSG00000157404 KIT H. sapiens SSL Slorth 0.978632 View
ENSG00000101266 CSNK2A1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.974269 View
ENSG00000116478 HDAC1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.973266 View
ENSG00000133703 KRAS ENSG00000157404 KIT H. sapiens SSL Slorth 0.973092 View
ENSG00000142208 AKT1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.972791 View
ENSG00000157404 KIT ENSG00000165409 TSHR H. sapiens SDL Slorth 0.972518 View
ENSG00000135486 HNRNPA1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.972438 View
ENSG00000157404 KIT ENSG00000189067 LITAF H. sapiens SDL Slorth 0.972233 View
ENSG00000141736 ERBB2 ENSG00000157404 KIT H. sapiens SSL Slorth 0.971895 View
ENSG00000124181 PLCG1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.971575 View
ENSG00000139687 RB1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.970705 View
ENSG00000110395 CBL ENSG00000157404 KIT H. sapiens SDL Slorth 0.970661 View
ENSG00000124181 PLCG1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.969991 View
ENSG00000157404 KIT ENSG00000213949 ITGA1 H. sapiens SDL Slorth 0.96985 View
ENSG00000141510 TP53 ENSG00000157404 KIT H. sapiens SDL Slorth 0.968538 View
ENSG00000157404 KIT ENSG00000186908 ZDHHC17 H. sapiens SDL Slorth 0.967733 View
ENSG00000157404 KIT ENSG00000206181 TCEB3B H. sapiens SDL Slorth 0.967057 View
ENSG00000132646 PCNA ENSG00000157404 KIT H. sapiens SDL Slorth 0.966661 View
ENSG00000101146 RAE1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.965913 View
ENSG00000080815 PSEN1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.964933 View
ENSG00000157404 KIT ENSG00000168036 CTNNB1 H. sapiens SDL Slorth 0.964431 View
ENSG00000113721 PDGFRB ENSG00000157404 KIT H. sapiens SSL Slorth 0.964333 View
ENSG00000142192 APP ENSG00000157404 KIT H. sapiens SSL Slorth 0.964294 View
ENSG00000148400 NOTCH1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.963759 View
ENSG00000157404 KIT ENSG00000157601 MX1 H. sapiens SDL Slorth 0.963526 View
ENSG00000157404 KIT ENSG00000169862 CTNND2 H. sapiens SDL Slorth 0.963384 View
ENSG00000109906 ZBTB16 ENSG00000157404 KIT H. sapiens SSL Slorth 0.962769 View
ENSG00000157404 KIT ENSG00000176720 BOK H. sapiens SDL Slorth 0.962632 View
ENSG00000150093 ITGB1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.961318 View
ENSG00000132155 RAF1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.960816 View
ENSG00000121879 PIK3CA ENSG00000157404 KIT H. sapiens SSL Slorth 0.960693 View