Gene Name
|
Gene ID
|
Diseases
|
Drugs
|
GO terms
|
Orthologs
|
ERBB2
|
ENSG00000141736
|
breast
ovarian
other tumour types
NSCLC
gastric
|
AFATINIB
LAPATINIB
PERTUZUMAB
TRASTUZUMAB
TRASTUZUMAB EMTANSINE
VANDETANIB
|
RNA polymerase I core binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
signal transducer, downstream of receptor, with protein tyrosine kinase activity
transmembrane signaling receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
protein C-terminus binding
protein phosphatase binding
identical protein binding
ErbB-3 class receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
protein dimerization activity
growth factor binding
|
let-23 (C. elegans)
Egfr (D. melanogaster)
|
KIT
|
ENSG00000157404
|
GIST
AML
TGCT
mastocytosis
mucosal melanoma
epithelioma
|
CABOZANTINIB
DASATINIB
IMATINIB
LENVATINIB
PAZOPANIB
PONATINIB
REGORAFENIB
SORAFENIB
SUNITINIB
|
protease binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
signal transducer, downstream of receptor, with protein tyrosine kinase activity
stem cell factor receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
cytokine binding
protein homodimerization activity
metal ion binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
|
Pvr (D. melanogaster)
|