KIT

ENSG00000157404 - H. sapiens

Pathways

Go term Description
GO:0002020 protease binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0005020 stem cell factor receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019955 cytokine binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Drugs

Drug name Description
CABOZANTINIB
DASATINIB Tyrosine-protein kinase ABL inhibitor
IMATINIB Tyrosine-protein kinase ABL inhibitor
LENVATINIB
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
PONATINIB Tyrosine-protein kinase ABL inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
GIST
AML
TGCT
mastocytosis
mucosal melanoma
epithelioma

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000143632 ACTA1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.914807 View
ENSG00000061938 TNK2 ENSG00000157404 KIT H. sapiens SSL Slorth 0.914799 View
ENSG00000072163 LIMS2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.914736 View
ENSG00000082146 STRADB ENSG00000157404 KIT H. sapiens SDL Slorth 0.914496 View
ENSG00000010017 RANBP9 ENSG00000157404 KIT H. sapiens SSL Slorth 0.91438 View
ENSG00000145506 NKD2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.91404 View
ENSG00000143847 PPFIA4 ENSG00000157404 KIT H. sapiens SDL Slorth 0.91404 View
ENSG00000136014 USP44 ENSG00000157404 KIT H. sapiens SDL Slorth 0.914029 View
ENSG00000085449 WDFY1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.913605 View
ENSG00000060069 CTDP1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.913603 View
ENSG00000151692 RNF144A ENSG00000157404 KIT H. sapiens SDL Slorth 0.913578 View
ENSG00000070476 ZXDC ENSG00000157404 KIT H. sapiens SDL Slorth 0.913568 View
ENSG00000004897 CDC27 ENSG00000157404 KIT H. sapiens SSL Slorth 0.913558 View
ENSG00000066923 STAG3 ENSG00000157404 KIT H. sapiens SDL Slorth 0.91348 View
ENSG00000106346 USP42 ENSG00000157404 KIT H. sapiens SDL Slorth 0.913354 View
ENSG00000079134 THOC1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.913267 View
ENSG00000079432 CIC ENSG00000157404 KIT H. sapiens SDL Slorth 0.913135 View
ENSG00000146232 NFKBIE ENSG00000157404 KIT H. sapiens SDL Slorth 0.913135 View
ENSG00000139687 RB1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.913066 View
ENSG00000135776 ABCB10 ENSG00000157404 KIT H. sapiens SDL Slorth 0.912978 View
ENSG00000156345 CDK20 ENSG00000157404 KIT H. sapiens SDL Slorth 0.912892 View
ENSG00000070718 AP3M2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.912883 View
ENSG00000079335 CDC14A ENSG00000157404 KIT H. sapiens SDL Slorth 0.912725 View
ENSG00000148730 EIF4EBP2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.912498 View
ENSG00000101365 IDH3B ENSG00000157404 KIT H. sapiens SDL Slorth 0.912438 View
ENSG00000095397 WHRN ENSG00000157404 KIT H. sapiens SDL Slorth 0.912411 View
ENSG00000107282 APBA1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.912411 View
ENSG00000039068 CDH1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.912332 View
ENSG00000153071 DAB2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.91209 View
ENSG00000100644 HIF1A ENSG00000157404 KIT H. sapiens SDL Slorth 0.912073 View
ENSG00000085185 BCORL1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.912062 View
ENSG00000100228 RAB36 ENSG00000157404 KIT H. sapiens SDL Slorth 0.912062 View
ENSG00000145331 TRMT10A ENSG00000157404 KIT H. sapiens SDL Slorth 0.912062 View
ENSG00000157404 KIT ENSG00000163485 ADORA1 H. sapiens SDL Slorth 0.912028 View
ENSG00000136944 LMX1B ENSG00000157404 KIT H. sapiens SDL Slorth 0.911842 View
ENSG00000151746 BICD1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.911842 View
ENSG00000150093 ITGB1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.911624 View
ENSG00000048462 TNFRSF17 ENSG00000157404 KIT H. sapiens SDL Slorth 0.91155 View
ENSG00000112592 TBP ENSG00000157404 KIT H. sapiens SSL Slorth 0.911481 View
ENSG00000075340 ADD2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.911414 View