KIT

ENSG00000157404 - H. sapiens

Pathways

Go term Description
GO:0002020 protease binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0005020 stem cell factor receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019955 cytokine binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Drugs

Drug name Description
CABOZANTINIB
DASATINIB Tyrosine-protein kinase ABL inhibitor
IMATINIB Tyrosine-protein kinase ABL inhibitor
LENVATINIB
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
PONATINIB Tyrosine-protein kinase ABL inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
GIST
AML
TGCT
mastocytosis
mucosal melanoma
epithelioma

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000157404 KIT ENSG00000178997 EXD1 H. sapiens SDL Slorth 0.920604 View
ENSG00000115507 OTX1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.920443 View
ENSG00000105737 GRIK5 ENSG00000157404 KIT H. sapiens SDL Slorth 0.920436 View
ENSG00000119048 UBE2B ENSG00000157404 KIT H. sapiens SSL Slorth 0.920354 View
ENSG00000138594 TMOD3 ENSG00000157404 KIT H. sapiens SDL Slorth 0.920332 View
ENSG00000153132 CLGN ENSG00000157404 KIT H. sapiens SDL Slorth 0.920332 View
ENSG00000157404 KIT ENSG00000163932 PRKCD H. sapiens SSL Slorth 0.920301 View
ENSG00000100372 SLC25A17 ENSG00000157404 KIT H. sapiens SDL Slorth 0.91979 View
ENSG00000153944 MSI2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.919397 View
ENSG00000157404 KIT ENSG00000170365 SMAD1 H. sapiens SSL Slorth 0.918918 View
ENSG00000105976 MET ENSG00000157404 KIT H. sapiens SDL Slorth 0.918646 View
ENSG00000128052 KDR ENSG00000157404 KIT H. sapiens SDL Slorth 0.918638 View
ENSG00000148908 RGS10 ENSG00000157404 KIT H. sapiens SDL Slorth 0.918551 View
ENSG00000072694 FCGR2B ENSG00000157404 KIT H. sapiens SDL Slorth 0.918548 View
ENSG00000149923 PPP4C ENSG00000157404 KIT H. sapiens SSL Slorth 0.918232 View
ENSG00000079337 RAPGEF3 ENSG00000157404 KIT H. sapiens SDL Slorth 0.918227 View
ENSG00000111875 ASF1A ENSG00000157404 KIT H. sapiens SSL Slorth 0.918122 View
ENSG00000086619 ERO1B ENSG00000157404 KIT H. sapiens SDL Slorth 0.917947 View
ENSG00000085999 RAD54L ENSG00000157404 KIT H. sapiens SDL Slorth 0.9179 View
ENSG00000142192 APP ENSG00000157404 KIT H. sapiens SDL Slorth 0.917782 View
ENSG00000157404 KIT ENSG00000175766 EIF4E1B H. sapiens SDL Slorth 0.917502 View
ENSG00000078114 NEBL ENSG00000157404 KIT H. sapiens SDL Slorth 0.917304 View
ENSG00000129354 AP1M2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.917289 View
ENSG00000103275 UBE2I ENSG00000157404 KIT H. sapiens SDL Slorth 0.917123 View
ENSG00000157404 KIT ENSG00000198087 CD2AP H. sapiens SDL Slorth 0.916962 View
ENSG00000112118 MCM3 ENSG00000157404 KIT H. sapiens SSL Slorth 0.916902 View
ENSG00000132964 CDK8 ENSG00000157404 KIT H. sapiens SSL Slorth 0.916778 View
ENSG00000157404 KIT ENSG00000197442 MAP3K5 H. sapiens SSL Slorth 0.916633 View
ENSG00000029639 TFB1M ENSG00000157404 KIT H. sapiens SDL Slorth 0.916392 View
ENSG00000157404 KIT ENSG00000178568 ERBB4 H. sapiens SSL Slorth 0.915811 View
ENSG00000139668 WDFY2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.915726 View
ENSG00000137073 UBAP2 ENSG00000157404 KIT H. sapiens SDL Slorth 0.915595 View
ENSG00000130561 SAG ENSG00000157404 KIT H. sapiens SDL Slorth 0.915564 View
ENSG00000153922 CHD1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.915415 View
ENSG00000149273 RPS3 ENSG00000157404 KIT H. sapiens SDL Slorth 0.915334 View
ENSG00000001626 CFTR ENSG00000157404 KIT H. sapiens SSL Slorth 0.91528 View
ENSG00000101665 SMAD7 ENSG00000157404 KIT H. sapiens SSL Slorth 0.915213 View
ENSG00000106299 WASL ENSG00000157404 KIT H. sapiens SSL Slorth 0.915015 View
ENSG00000117748 RPA2 ENSG00000157404 KIT H. sapiens SSL Slorth 0.914986 View
ENSG00000116473 RAP1A ENSG00000157404 KIT H. sapiens SSL Slorth 0.914824 View