SMAD7 - KIT

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
SMAD7	ENSG00000101665	No diseases in record	No drugs in record	transcription factor activity, sequence-specific DNA binding protein binding collagen binding beta-catenin binding transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity ubiquitin protein ligase binding type I transforming growth factor beta receptor binding transcription regulatory region DNA binding metal ion binding activin binding I-SMAD binding	daf-14 (C. elegans) daf-8 (C. elegans) Dad (D. melanogaster)
KIT	ENSG00000157404	GIST AML TGCT mastocytosis mucosal melanoma epithelioma	CABOZANTINIB DASATINIB IMATINIB LENVATINIB PAZOPANIB PONATINIB REGORAFENIB SORAFENIB SUNITINIB	protease binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity stem cell factor receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding cytokine binding protein homodimerization activity metal ion binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Pvr (D. melanogaster)