KIT

ENSG00000157404 - H. sapiens

Pathways

Go term Description
GO:0002020 protease binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0005020 stem cell factor receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019955 cytokine binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Drugs

Drug name Description
CABOZANTINIB
DASATINIB Tyrosine-protein kinase ABL inhibitor
IMATINIB Tyrosine-protein kinase ABL inhibitor
LENVATINIB
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
PONATINIB Tyrosine-protein kinase ABL inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SORAFENIB Serine/threonine-protein kinase RAF inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
GIST
AML
TGCT
mastocytosis
mucosal melanoma
epithelioma

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000157404 KIT ENSG00000173404 INSM1 H. sapiens SDL Slorth 0.960214 View
ENSG00000123124 WWP1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.958502 View
ENSG00000109971 HSPA8 ENSG00000157404 KIT H. sapiens SSL Slorth 0.958254 View
ENSG00000157404 KIT ENSG00000185896 LAMP1 H. sapiens SDL Slorth 0.95793 View
ENSG00000157404 KIT ENSG00000198353 HOXC4 H. sapiens SDL Slorth 0.957902 View
ENSG00000157404 KIT ENSG00000172367 PDZD3 H. sapiens SDL Slorth 0.957733 View
ENSG00000157404 KIT ENSG00000165115 KIF27 H. sapiens SDL Slorth 0.957733 View
ENSG00000157404 KIT ENSG00000162889 MAPKAPK2 H. sapiens SDL Slorth 0.957314 View
ENSG00000157404 KIT ENSG00000205629 LCMT1 H. sapiens SDL Slorth 0.957109 View
ENSG00000157404 KIT ENSG00000160145 KALRN H. sapiens SDL Slorth 0.956795 View
ENSG00000157404 KIT ENSG00000159496 RGL4 H. sapiens SDL Slorth 0.955304 View
ENSG00000157404 KIT ENSG00000184012 TMPRSS2 H. sapiens SDL Slorth 0.955069 View
ENSG00000136997 MYC ENSG00000157404 KIT H. sapiens SDL Slorth 0.955068 View
ENSG00000157404 KIT ENSG00000184470 TXNRD2 H. sapiens SDL Slorth 0.955017 View
ENSG00000004700 RECQL ENSG00000157404 KIT H. sapiens SSL Slorth 0.95487 View
ENSG00000134853 PDGFRA ENSG00000157404 KIT H. sapiens SSL Slorth 0.954586 View
ENSG00000113721 PDGFRB ENSG00000157404 KIT H. sapiens SDL Slorth 0.95457 View
ENSG00000091831 ESR1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.954419 View
ENSG00000157404 KIT ENSG00000171150 SOCS5 H. sapiens SDL Slorth 0.954253 View
ENSG00000070010 UFD1L ENSG00000157404 KIT H. sapiens SSL Slorth 0.954143 View
ENSG00000101868 POLA1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.953736 View
ENSG00000146648 EGFR ENSG00000157404 KIT H. sapiens SSL Slorth 0.953456 View
ENSG00000097046 CDC7 ENSG00000157404 KIT H. sapiens SSL Slorth 0.953233 View
ENSG00000157404 KIT ENSG00000164736 SOX17 H. sapiens SDL Slorth 0.953174 View
ENSG00000157404 KIT ENSG00000240771 ARHGEF25 H. sapiens SDL Slorth 0.953015 View
ENSG00000128245 YWHAH ENSG00000157404 KIT H. sapiens SSL Slorth 0.952918 View
ENSG00000007908 SELE ENSG00000157404 KIT H. sapiens SDL Slorth 0.952854 View
ENSG00000157404 KIT ENSG00000204103 MAFB H. sapiens SDL Slorth 0.952504 View
ENSG00000073969 NSF ENSG00000157404 KIT H. sapiens SSL Slorth 0.952277 View
ENSG00000075624 ACTB ENSG00000157404 KIT H. sapiens SSL Slorth 0.952066 View
ENSG00000138376 BARD1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.951766 View
ENSG00000104365 IKBKB ENSG00000157404 KIT H. sapiens SDL Slorth 0.95172 View
ENSG00000139219 COL2A1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.951402 View
ENSG00000149554 CHEK1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.950839 View
ENSG00000148400 NOTCH1 ENSG00000157404 KIT H. sapiens SDL Slorth 0.950565 View
ENSG00000101266 CSNK2A1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.950548 View
ENSG00000135604 STX11 ENSG00000157404 KIT H. sapiens SDL Slorth 0.950329 View
ENSG00000147010 SH3KBP1 ENSG00000157404 KIT H. sapiens SSL Slorth 0.95025 View
ENSG00000102683 SGCG ENSG00000157404 KIT H. sapiens SDL Slorth 0.950212 View
ENSG00000157404 KIT ENSG00000166341 DCHS1 H. sapiens SDL Slorth 0.949985 View