KIT - CTNNB1

H. sapiens

SDL interaction

Identifiers

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
KIT	ENSG00000157404	GIST AML TGCT mastocytosis mucosal melanoma epithelioma	CABOZANTINIB DASATINIB IMATINIB LENVATINIB PAZOPANIB PONATINIB REGORAFENIB SORAFENIB SUNITINIB	protease binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine kinase activity stem cell factor receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding cytokine binding protein homodimerization activity metal ion binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Pvr (D. melanogaster)
CTNNB1	ENSG00000168036	colorectal ovarian hepatoblastoma pleomorphic salivary gland adenoma other tumour types	No drugs in record	RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity signal transducer activity protein binding protein C-terminus binding transcription factor binding enzyme binding kinase binding protein kinase binding protein phosphatase binding estrogen receptor binding nuclear hormone receptor binding transcription regulatory region DNA binding ion channel binding alpha-catenin binding cadherin binding SMAD binding protein heterodimerization activity androgen receptor binding I-SMAD binding repressing transcription factor binding cadherin binding involved in cell-cell adhesion euchromatin binding	bar-1 (C. elegans) hmp-2 (C. elegans) arm (D. melanogaster)