MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000169032 MAP2K1 ENSG00000171824 EXOSC10 H. sapiens SSL Slorth 0.7642 View
ENSG00000169032 MAP2K1 ENSG00000174775 HRAS H. sapiens SSL Slorth 0.763923 View
ENSG00000139613 SMARCC2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.762566 View
ENSG00000143632 ACTA1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.761679 View
ENSG00000122565 CBX3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.760822 View
ENSG00000069399 BCL3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.758908 View
ENSG00000105976 MET ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.756232 View
ENSG00000077782 FGFR1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.756029 View
ENSG00000165392 WRN ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.755256 View
ENSG00000149923 PPP4C ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.754672 View
ENSG00000114302 PRKAR2A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.75447 View
ENSG00000169032 MAP2K1 ENSG00000170734 POLH H. sapiens SSL Slorth 0.753535 View
ENSG00000112658 SRF ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.752662 View
ENSG00000100142 POLR2F ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.751827 View
ENSG00000130396 AFDN ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.751166 View