MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000141367 CLTC ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.888908 View
ENSG00000169032 MAP2K1 ENSG00000283094 PTEN H. sapiens SSL Slorth 0.888711 View
ENSG00000169032 MAP2K1 ENSG00000171105 INSR H. sapiens SSL Slorth 0.888517 View
ENSG00000072803 FBXW11 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.888516 View
ENSG00000102882 MAPK3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.8881 View
ENSG00000132170 PPARG ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.887156 View
ENSG00000169032 MAP2K1 ENSG00000169375 SIN3A H. sapiens SSL Slorth 0.886302 View
ENSG00000141543 EIF4A3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.886236 View
ENSG00000169032 MAP2K1 ENSG00000198742 SMURF1 H. sapiens SSL Slorth 0.885984 View
ENSG00000114867 EIF4G1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.885524 View
ENSG00000168496 FEN1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.885447 View
ENSG00000107581 EIF3A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.885358 View
ENSG00000115904 SOS1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.884952 View
ENSG00000133316 WDR74 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.884128 View
ENSG00000060069 CTDP1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.88378 View
ENSG00000169032 MAP2K1 ENSG00000188612 SUMO2 H. sapiens SSL Slorth 0.88349 View
ENSG00000110107 PRPF19 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.883151 View
ENSG00000130177 CDC16 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.882787 View
ENSG00000117133 RPF1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.882654 View
ENSG00000092201 SUPT16H ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.882415 View
ENSG00000065559 MAP2K4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.880615 View
ENSG00000124813 RUNX2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.880051 View
ENSG00000094880 CDC23 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.879187 View
ENSG00000121481 RNF2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.878123 View
ENSG00000165731 RET ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.877841 View
ENSG00000109906 ZBTB16 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.876882 View
ENSG00000134853 PDGFRA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.875574 View
ENSG00000107404 DVL1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.874434 View
ENSG00000111875 ASF1A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.873769 View
ENSG00000114767 RRP9 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.873728 View
ENSG00000113456 RAD1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.873029 View
ENSG00000169032 MAP2K1 ENSG00000245848 CEBPA H. sapiens SSL Slorth 0.872877 View
ENSG00000169032 MAP2K1 ENSG00000198668 CALM1 H. sapiens SSL Slorth 0.871374 View
ENSG00000158402 CDC25C ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.87109 View
ENSG00000105325 FZR1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.870845 View
ENSG00000114166 KAT2B ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.870143 View
ENSG00000156970 BUB1B ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.869606 View
ENSG00000169032 MAP2K1 ENSG00000169139 UBE2V2 H. sapiens SSL Slorth 0.869221 View
ENSG00000129152 MYOD1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.867749 View
ENSG00000169032 MAP2K1 ENSG00000196235 SUPT5H H. sapiens SSL Slorth 0.866517 View