PDGFRA

ENSG00000134853 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005018 platelet-derived growth factor alpha-receptor activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0038085 vascular endothelial growth factor binding
GO:0042803 protein homodimerization activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048407 platelet-derived growth factor binding

Drugs

Drug name Description
BECAPLERMIN Platelet-derived growth factor receptor agonist
LENVATINIB
NINTEDANIB Platelet-derived growth factor receptor inhibitor
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
PONATINIB Tyrosine-protein kinase ABL inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
GIST
idiopathic hypereosinophilic syndrome
paediatric glioblastoma

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000134853 PDGFRA ENSG00000198900 TOP1 H. sapiens SSL BioGRID 1.0 View
ENSG00000134853 PDGFRA ENSG00000134086 VHL H. sapiens SSL BioGRID 1.0 View
ENSG00000012048 BRCA1 ENSG00000134853 PDGFRA H. sapiens SSL BioGRID 1.0 View
ENSG00000136807 CDK9 ENSG00000134853 PDGFRA H. sapiens SSL BioGRID 1.0 View
ENSG00000198793 MTOR ENSG00000134853 PDGFRA H. sapiens SSL BioGRID 1.0 View
ENSG00000134853 PDGFRA ENSG00000171848 RRM2 H. sapiens SSL BioGRID 1.0 View
ENSG00000100393 EP300 ENSG00000134853 PDGFRA H. sapiens SDL Slorth 0.988568 View
ENSG00000116478 HDAC1 ENSG00000134853 PDGFRA H. sapiens SDL Slorth 0.988012 View
ENSG00000005339 CREBBP ENSG00000134853 PDGFRA H. sapiens SDL Slorth 0.987432 View
ENSG00000110395 CBL ENSG00000134853 PDGFRA H. sapiens SDL Slorth 0.985682 View
ENSG00000134853 PDGFRA ENSG00000150991 UBC H. sapiens SDL Slorth 0.982853 View
ENSG00000134853 PDGFRA ENSG00000149554 CHEK1 H. sapiens SSL Slorth 0.975586 View
ENSG00000134853 PDGFRA ENSG00000172977 KAT5 H. sapiens SSL Slorth 0.971557 View
ENSG00000134853 PDGFRA ENSG00000197122 SRC H. sapiens SDL Slorth 0.971332 View
ENSG00000134853 PDGFRA ENSG00000165392 WRN H. sapiens SSL Slorth 0.971108 View
ENSG00000134853 PDGFRA ENSG00000156970 BUB1B H. sapiens SSL Slorth 0.970775 View
ENSG00000100030 MAPK1 ENSG00000134853 PDGFRA H. sapiens SDL Slorth 0.970011 View
ENSG00000134853 PDGFRA ENSG00000177885 GRB2 H. sapiens SDL Slorth 0.969732 View
ENSG00000124181 PLCG1 ENSG00000134853 PDGFRA H. sapiens SDL Slorth 0.969405 View
ENSG00000134853 PDGFRA ENSG00000136450 SRSF1 H. sapiens SSL Slorth 0.96935 View
ENSG00000134853 PDGFRA ENSG00000168148 HIST3H3 H. sapiens SSL Slorth 0.968972 View
ENSG00000134853 PDGFRA ENSG00000168610 STAT3 H. sapiens SDL Slorth 0.968095 View
ENSG00000134853 PDGFRA ENSG00000169083 AR H. sapiens SDL Slorth 0.968068 View
ENSG00000134853 PDGFRA ENSG00000166851 PLK1 H. sapiens SSL Slorth 0.968057 View
ENSG00000134853 PDGFRA ENSG00000172531 PPP1CA H. sapiens SSL Slorth 0.967789 View
ENSG00000134853 PDGFRA ENSG00000141510 TP53 H. sapiens SDL Slorth 0.967686 View
ENSG00000134853 PDGFRA ENSG00000166508 MCM7 H. sapiens SSL Slorth 0.967507 View
ENSG00000134853 PDGFRA ENSG00000170345 FOS H. sapiens SSL Slorth 0.967451 View
ENSG00000134853 PDGFRA ENSG00000186868 MAPT H. sapiens SSL Slorth 0.967299 View
ENSG00000134853 PDGFRA ENSG00000188486 H2AFX H. sapiens SSL Slorth 0.967215 View
ENSG00000132646 PCNA ENSG00000134853 PDGFRA H. sapiens SDL Slorth 0.967215 View
ENSG00000134853 PDGFRA ENSG00000144028 SNRNP200 H. sapiens SSL Slorth 0.966857 View
ENSG00000134853 PDGFRA ENSG00000145386 CCNA2 H. sapiens SSL Slorth 0.966823 View
ENSG00000134853 PDGFRA ENSG00000150459 SAP18 H. sapiens SSL Slorth 0.966551 View
ENSG00000134853 PDGFRA ENSG00000173473 SMARCC1 H. sapiens SSL Slorth 0.966465 View
ENSG00000134853 PDGFRA ENSG00000184900 SUMO3 H. sapiens SSL Slorth 0.966454 View
ENSG00000109670 FBXW7 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.965357 View
ENSG00000134853 PDGFRA ENSG00000134982 APC H. sapiens SSL Slorth 0.965113 View
ENSG00000134853 PDGFRA ENSG00000253729 PRKDC H. sapiens SSL Slorth 0.9649 View
ENSG00000134853 PDGFRA ENSG00000197299 BLM H. sapiens SSL Slorth 0.964812 View