PDGFRA

ENSG00000134853 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005018 platelet-derived growth factor alpha-receptor activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0038085 vascular endothelial growth factor binding
GO:0042803 protein homodimerization activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048407 platelet-derived growth factor binding

Drugs

Drug name Description
BECAPLERMIN Platelet-derived growth factor receptor agonist
LENVATINIB
NINTEDANIB Platelet-derived growth factor receptor inhibitor
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
PONATINIB Tyrosine-protein kinase ABL inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
GIST
idiopathic hypereosinophilic syndrome
paediatric glioblastoma

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000134853 PDGFRA ENSG00000140443 IGF1R H. sapiens SSL Slorth 0.957132 View
ENSG00000134853 PDGFRA ENSG00000145604 SKP2 H. sapiens SSL Slorth 0.956999 View
ENSG00000134853 PDGFRA ENSG00000143799 PARP1 H. sapiens SSL Slorth 0.956986 View
ENSG00000134853 PDGFRA ENSG00000196470 SIAH1 H. sapiens SSL Slorth 0.956874 View
ENSG00000134853 PDGFRA ENSG00000154229 PRKCA H. sapiens SSL Slorth 0.956746 View
ENSG00000134853 PDGFRA ENSG00000175387 SMAD2 H. sapiens SSL Slorth 0.956467 View
ENSG00000100644 HIF1A ENSG00000134853 PDGFRA H. sapiens SDL Slorth 0.95643 View
ENSG00000134853 PDGFRA ENSG00000168283 BMI1 H. sapiens SSL Slorth 0.956175 View
ENSG00000111276 CDKN1B ENSG00000134853 PDGFRA H. sapiens SDL Slorth 0.956119 View
ENSG00000134853 PDGFRA ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.955591 View
ENSG00000134853 PDGFRA ENSG00000165731 RET H. sapiens SSL Slorth 0.955067 View
ENSG00000134853 PDGFRA ENSG00000157404 KIT H. sapiens SSL Slorth 0.954586 View
ENSG00000134853 PDGFRA ENSG00000198742 SMURF1 H. sapiens SSL Slorth 0.954567 View
ENSG00000134853 PDGFRA ENSG00000196235 SUPT5H H. sapiens SSL Slorth 0.954552 View
ENSG00000005339 CREBBP ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.954466 View
ENSG00000134853 PDGFRA ENSG00000184634 MED12 H. sapiens SSL Slorth 0.954434 View
ENSG00000134853 PDGFRA ENSG00000170027 YWHAG H. sapiens SSL Slorth 0.954254 View
ENSG00000134853 PDGFRA ENSG00000151247 EIF4E H. sapiens SSL Slorth 0.95397 View
ENSG00000134853 PDGFRA ENSG00000135486 HNRNPA1 H. sapiens SSL Slorth 0.953932 View
ENSG00000134853 PDGFRA ENSG00000159692 CTBP1 H. sapiens SSL Slorth 0.953307 View
ENSG00000134853 PDGFRA ENSG00000181163 NPM1 H. sapiens SSL Slorth 0.953303 View
ENSG00000134853 PDGFRA ENSG00000148400 NOTCH1 H. sapiens SSL Slorth 0.952468 View
ENSG00000134853 PDGFRA ENSG00000178568 ERBB4 H. sapiens SSL Slorth 0.952403 View
ENSG00000134853 PDGFRA ENSG00000177889 UBE2N H. sapiens SSL Slorth 0.952113 View
ENSG00000101266 CSNK2A1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.95209 View
ENSG00000134853 PDGFRA ENSG00000162231 NXF1 H. sapiens SSL Slorth 0.951794 View
ENSG00000134853 PDGFRA ENSG00000159216 RUNX1 H. sapiens SSL Slorth 0.951329 View
ENSG00000134853 PDGFRA ENSG00000175390 EIF3F H. sapiens SSL Slorth 0.95077 View
ENSG00000134853 PDGFRA ENSG00000175792 RUVBL1 H. sapiens SSL Slorth 0.950014 View
ENSG00000134853 PDGFRA ENSG00000167986 DDB1 H. sapiens SSL Slorth 0.949416 View
ENSG00000134853 PDGFRA ENSG00000169047 IRS1 H. sapiens SSL Slorth 0.949397 View
ENSG00000012048 BRCA1 ENSG00000134853 PDGFRA H. sapiens SDL Slorth 0.949317 View
ENSG00000123374 CDK2 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.949264 View
ENSG00000134853 PDGFRA ENSG00000147133 TAF1 H. sapiens SSL Slorth 0.949252 View
ENSG00000134853 PDGFRA ENSG00000182866 LCK H. sapiens SSL Slorth 0.948659 View
ENSG00000134853 PDGFRA ENSG00000164109 MAD2L1 H. sapiens SSL Slorth 0.948221 View
ENSG00000134853 PDGFRA ENSG00000168496 FEN1 H. sapiens SSL Slorth 0.947892 View
ENSG00000134853 PDGFRA ENSG00000141564 RPTOR H. sapiens SSL Slorth 0.947885 View
ENSG00000122406 RPL5 ENSG00000134853 PDGFRA H. sapiens SDL Slorth 0.94783 View
ENSG00000134853 PDGFRA ENSG00000163932 PRKCD H. sapiens SSL Slorth 0.947809 View