PDGFRA

ENSG00000134853 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005018 platelet-derived growth factor alpha-receptor activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0038085 vascular endothelial growth factor binding
GO:0042803 protein homodimerization activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048407 platelet-derived growth factor binding

Drugs

Drug name Description
BECAPLERMIN Platelet-derived growth factor receptor agonist
LENVATINIB
NINTEDANIB Platelet-derived growth factor receptor inhibitor
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
PONATINIB Tyrosine-protein kinase ABL inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
GIST
idiopathic hypereosinophilic syndrome
paediatric glioblastoma

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000084774 CAD ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.809973 View
ENSG00000134853 PDGFRA ENSG00000170606 HSPA4 H. sapiens SSL Slorth 0.809664 View
ENSG00000134853 PDGFRA ENSG00000163041 H3F3A H. sapiens SSL Slorth 0.808734 View
ENSG00000114166 KAT2B ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.807902 View
ENSG00000067560 RHOA ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.806229 View
ENSG00000101665 SMAD7 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.806135 View
ENSG00000114867 EIF4G1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.805551 View
ENSG00000134853 PDGFRA ENSG00000171223 JUNB H. sapiens SSL Slorth 0.803925 View
ENSG00000134853 PDGFRA ENSG00000160208 RRP1B H. sapiens SSL Slorth 0.803288 View
ENSG00000036257 CUL3 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.800173 View
ENSG00000023445 BIRC3 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.800111 View
ENSG00000124813 RUNX2 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.797673 View
ENSG00000072062 PRKACA ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.79694 View
ENSG00000131747 TOP2A ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.796761 View
ENSG00000130726 TRIM28 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.7946 View
ENSG00000134853 PDGFRA ENSG00000142208 AKT1 H. sapiens SSL Slorth 0.793711 View
ENSG00000134853 PDGFRA ENSG00000157933 SKI H. sapiens SSL Slorth 0.793445 View
ENSG00000101161 PRPF6 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.792328 View
ENSG00000134853 PDGFRA ENSG00000143933 CALM2 H. sapiens SSL Slorth 0.791013 View
ENSG00000134853 PDGFRA ENSG00000166949 SMAD3 H. sapiens SSL Slorth 0.790722 View
ENSG00000100138 SNU13 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.789457 View
ENSG00000107404 DVL1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.789048 View
ENSG00000134853 PDGFRA ENSG00000169083 AR H. sapiens SSL Slorth 0.788885 View
ENSG00000134853 PDGFRA ENSG00000163960 UBXN7 H. sapiens SSL Slorth 0.788861 View
ENSG00000134853 PDGFRA ENSG00000165916 PSMC3 H. sapiens SSL Slorth 0.786939 View
ENSG00000134853 PDGFRA ENSG00000188021 UBQLN2 H. sapiens SSL Slorth 0.786933 View
ENSG00000134853 PDGFRA ENSG00000161057 PSMC2 H. sapiens SSL Slorth 0.784041 View
ENSG00000134853 PDGFRA ENSG00000181788 SIAH2 H. sapiens SSL Slorth 0.783962 View
ENSG00000134853 PDGFRA ENSG00000167658 EEF2 H. sapiens SSL Slorth 0.780269 View
ENSG00000134853 PDGFRA ENSG00000198400 NTRK1 H. sapiens SSL Slorth 0.780245 View
ENSG00000134853 PDGFRA ENSG00000154611 PSMA8 H. sapiens SSL Slorth 0.775085 View
ENSG00000055130 CUL1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.774257 View
ENSG00000077097 TOP2B ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.773952 View
ENSG00000085832 EPS15 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.772089 View
ENSG00000103197 TSC2 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.769123 View
ENSG00000061938 TNK2 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.766666 View
ENSG00000118689 FOXO3 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.766575 View
ENSG00000134853 PDGFRA ENSG00000137076 TLN1 H. sapiens SSL Slorth 0.765425 View
ENSG00000134853 PDGFRA ENSG00000141552 ANAPC11 H. sapiens SSL Slorth 0.765309 View
ENSG00000116288 PARK7 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.764291 View