PDGFRA

ENSG00000134853 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005018 platelet-derived growth factor alpha-receptor activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0038085 vascular endothelial growth factor binding
GO:0042803 protein homodimerization activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048407 platelet-derived growth factor binding

Drugs

Drug name Description
BECAPLERMIN Platelet-derived growth factor receptor agonist
LENVATINIB
NINTEDANIB Platelet-derived growth factor receptor inhibitor
PAZOPANIB Tyrosine-protein kinase LCK inhibitor
PONATINIB Tyrosine-protein kinase ABL inhibitor
REGORAFENIB Tyrosine-protein kinase ABL inhibitor
SUNITINIB Macrophage colony stimulating factor receptor inhibitor

Diseases

Disease Name
GIST
idiopathic hypereosinophilic syndrome
paediatric glioblastoma

Orthologs

Gene Organism
Pvr D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000134853 PDGFRA ENSG00000136997 MYC H. sapiens SSL Slorth 0.87507 View
ENSG00000078140 UBE2K ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.874795 View
ENSG00000134853 PDGFRA ENSG00000164934 DCAF13 H. sapiens SSL Slorth 0.87384 View
ENSG00000134853 PDGFRA ENSG00000168610 STAT3 H. sapiens SSL Slorth 0.872344 View
ENSG00000075624 ACTB ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.871954 View
ENSG00000124486 USP9X ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.871534 View
ENSG00000134853 PDGFRA ENSG00000169375 SIN3A H. sapiens SSL Slorth 0.870964 View
ENSG00000134057 CCNB1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.87063 View
ENSG00000134853 PDGFRA ENSG00000178950 GAK H. sapiens SSL Slorth 0.870359 View
ENSG00000078747 ITCH ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.869665 View
ENSG00000116478 HDAC1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.869527 View
ENSG00000127511 SIN3B ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.869391 View
ENSG00000109320 NFKB1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.869209 View
ENSG00000134853 PDGFRA ENSG00000161547 SRSF2 H. sapiens SSL Slorth 0.868943 View
ENSG00000108424 KPNB1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.866841 View
ENSG00000134853 PDGFRA ENSG00000164045 CDC25A H. sapiens SSL Slorth 0.866454 View
ENSG00000134853 PDGFRA ENSG00000170734 POLH H. sapiens SSL Slorth 0.866334 View
ENSG00000134853 PDGFRA ENSG00000213923 CSNK1E H. sapiens SSL Slorth 0.864904 View
ENSG00000134853 PDGFRA ENSG00000154582 TCEB1 H. sapiens SSL Slorth 0.864774 View
ENSG00000134853 PDGFRA ENSG00000142192 APP H. sapiens SSL Slorth 0.863789 View
ENSG00000134853 PDGFRA ENSG00000175793 SFN H. sapiens SSL Slorth 0.863753 View
ENSG00000089159 PXN ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.862073 View
ENSG00000134853 PDGFRA ENSG00000177606 JUN H. sapiens SSL Slorth 0.860754 View
ENSG00000080824 HSP90AA1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.860191 View
ENSG00000103194 USP10 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.859386 View
ENSG00000005007 UPF1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.858971 View
ENSG00000134853 PDGFRA ENSG00000179091 CYC1 H. sapiens SSL Slorth 0.85854 View
ENSG00000070831 CDC42 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.858247 View
ENSG00000099956 SMARCB1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.856654 View
ENSG00000134853 PDGFRA ENSG00000175104 TRAF6 H. sapiens SSL Slorth 0.8556 View
ENSG00000103126 AXIN1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.855126 View
ENSG00000134853 PDGFRA ENSG00000153201 RANBP2 H. sapiens SSL Slorth 0.854666 View
ENSG00000047315 POLR2B ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.854406 View
ENSG00000134853 PDGFRA ENSG00000164924 YWHAZ H. sapiens SSL Slorth 0.853944 View
ENSG00000093009 CDC45 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.853386 View
ENSG00000134853 PDGFRA ENSG00000159352 PSMD4 H. sapiens SSL Slorth 0.852526 View
ENSG00000072518 MARK2 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.851639 View
ENSG00000134853 PDGFRA ENSG00000149480 MTA2 H. sapiens SSL Slorth 0.850623 View
ENSG00000126261 UBA2 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.848252 View
ENSG00000117676 RPS6KA1 ENSG00000134853 PDGFRA H. sapiens SSL Slorth 0.847992 View