PDGFRA - TOP1

H. sapiens

SSL interaction

Identifiers

Gene Name Gene ID Diseases Drugs GO terms Orthologs
PDGFRA ENSG00000134853 GIST
idiopathic hypereosinophilic syndrome
paediatric glioblastoma
BECAPLERMIN
LENVATINIB
NINTEDANIB
PAZOPANIB
PONATINIB
REGORAFENIB
SUNITINIB
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
platelet-derived growth factor alpha-receptor activity
vascular endothelial growth factor-activated receptor activity
Ras guanyl-nucleotide exchange factor activity
platelet-derived growth factor receptor binding
protein binding
ATP binding
vascular endothelial growth factor binding
protein homodimerization activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
platelet-derived growth factor binding
Pvr (D. melanogaster)
TOP1 ENSG00000198900 AML*
IRINOTECAN
core promoter sequence-specific DNA binding
DNA binding
chromatin binding
DNA topoisomerase type I activity
protein binding
isomerase activity
DNA topoisomerase activity
TOP1 (S. cerevisiae)
top-1 (C. elegans)
Top1 (D. melanogaster)

References