MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000169032 MAP2K1 ENSG00000254087 LYN H. sapiens SSL Slorth 0.923528 View
ENSG00000132341 RAN ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.923376 View
ENSG00000157106 SMG1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.923297 View
ENSG00000114062 UBE3A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.923209 View
ENSG00000169032 MAP2K1 ENSG00000187555 USP7 H. sapiens SSL Slorth 0.923159 View
ENSG00000126457 PRMT1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.922615 View
ENSG00000103194 USP10 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.922561 View
ENSG00000103126 AXIN1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.922553 View
ENSG00000131759 RARA ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.922469 View
ENSG00000121774 KHDRBS1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.922389 View
ENSG00000119048 UBE2B ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.922316 View
ENSG00000169032 MAP2K1 ENSG00000172531 PPP1CA H. sapiens SSL Slorth 0.921976 View
ENSG00000112118 MCM3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.921797 View
ENSG00000085733 CTTN ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.921752 View
ENSG00000169032 MAP2K1 ENSG00000169045 HNRNPH1 H. sapiens SSL Slorth 0.921699 View
ENSG00000101665 SMAD7 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.921382 View
ENSG00000169032 MAP2K1 ENSG00000182866 LCK H. sapiens SSL Slorth 0.921294 View
ENSG00000139687 RB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.921217 View
ENSG00000069869 NEDD4 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.92099 View
ENSG00000123124 WWP1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.920972 View
ENSG00000136450 SRSF1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.920834 View
ENSG00000080815 PSEN1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.92045 View
ENSG00000169032 MAP2K1 ENSG00000175793 SFN H. sapiens SDL Slorth 0.919521 View
ENSG00000129559 NEDD8 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.91952 View
ENSG00000039068 CDH1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.919111 View
ENSG00000147010 SH3KBP1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.918795 View
ENSG00000169032 MAP2K1 ENSG00000178568 ERBB4 H. sapiens SSL Slorth 0.918793 View
ENSG00000105568 PPP2R1A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.918707 View
ENSG00000096968 JAK2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.918595 View
ENSG00000069329 VPS35 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.91841 View
ENSG00000100811 YY1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.918205 View
ENSG00000169032 MAP2K1 ENSG00000175766 EIF4E1B H. sapiens SDL Slorth 0.918203 View
ENSG00000145604 SKP2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.917611 View
ENSG00000108055 SMC3 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.917479 View
ENSG00000169032 MAP2K1 ENSG00000244687 UBE2V1 H. sapiens SSL Slorth 0.917054 View
ENSG00000131467 PSME3 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.916989 View
ENSG00000110107 PRPF19 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.916953 View
ENSG00000169032 MAP2K1 ENSG00000198793 MTOR H. sapiens SSL Slorth 0.916735 View
ENSG00000169032 MAP2K1 ENSG00000169047 IRS1 H. sapiens SSL Slorth 0.916482 View
ENSG00000156052 GNAQ ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.916467 View