MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000067560 RHOA ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.946861 View
ENSG00000108298 RPL19 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.946366 View
ENSG00000070010 UFD1L ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.946148 View
ENSG00000089159 PXN ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.946128 View
ENSG00000143106 PSMA5 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.946015 View
ENSG00000113558 SKP1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.945957 View
ENSG00000141480 ARRB2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.945662 View
ENSG00000124762 CDKN1A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.945457 View
ENSG00000166851 PLK1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.945268 View
ENSG00000162231 NXF1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.945191 View
ENSG00000004897 CDC27 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.945181 View
ENSG00000072401 UBE2D1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.945127 View
ENSG00000149273 RPS3 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.945042 View
ENSG00000141480 ARRB2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.944912 View
ENSG00000160691 SHC1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.944714 View
ENSG00000132155 RAF1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.944609 View
ENSG00000134086 VHL ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.943906 View
ENSG00000163930 BAP1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.943848 View
ENSG00000111276 CDKN1B ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.943545 View
ENSG00000142192 APP ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.943392 View
ENSG00000126067 PSMB2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.943003 View
ENSG00000008018 PSMB1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.94295 View
ENSG00000164109 MAD2L1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.94294 View
ENSG00000082898 XPO1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.942933 View
ENSG00000138069 RAB1A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.94281 View
ENSG00000010810 FYN ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.942756 View
ENSG00000087586 AURKA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.942649 View
ENSG00000131759 RARA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.942567 View
ENSG00000169032 MAP2K1 ENSG00000197299 BLM H. sapiens SSL Slorth 0.942499 View
ENSG00000149136 SSRP1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.942457 View
ENSG00000169032 MAP2K1 ENSG00000175197 DDIT3 H. sapiens SDL Slorth 0.941915 View
ENSG00000169032 MAP2K1 ENSG00000177981 ASB8 H. sapiens SDL Slorth 0.9419 View
ENSG00000143799 PARP1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.94114 View
ENSG00000114423 CBLB ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.940946 View
ENSG00000159692 CTBP1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.940817 View
ENSG00000168283 BMI1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.940623 View
ENSG00000036257 CUL3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.940572 View
ENSG00000135341 MAP3K7 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.94037 View
ENSG00000135018 UBQLN1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.940154 View
ENSG00000127511 SIN3B ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.939982 View