RAF1 - MAP2K1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
RAF1	ENSG00000132155	pilocytic astrocytoma prostate	REGORAFENIB SORAFENIB	protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity protein binding ATP binding kinase activity enzyme binding mitogen-activated protein kinase kinase binding identical protein binding metal ion binding protein heterodimerization activity small GTPase binding	lin-45 (C. elegans)
MAP2K1	ENSG00000169032	NSCLC melanoma colorectal	TRAMETINIB	protein kinase activity protein serine/threonine kinase activity signal transducer, downstream of receptor, with serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine phosphatase activity protein binding ATP binding protein C-terminus binding protein kinase binding protein serine/threonine kinase activator activity protein N-terminus binding	PBS2 (S. cerevisiae) mek-2 (C. elegans) Dsor1 (D. melanogaster)