MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000169032 MAP2K1 ENSG00000198087 CD2AP H. sapiens SDL Slorth 0.933575 View
ENSG00000169032 MAP2K1 ENSG00000175387 SMAD2 H. sapiens SSL Slorth 0.933574 View
ENSG00000169032 MAP2K1 ENSG00000213341 CHUK H. sapiens SSL Slorth 0.933492 View
ENSG00000169032 MAP2K1 ENSG00000186868 MAPT H. sapiens SSL Slorth 0.933402 View
ENSG00000130939 UBE4B ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.932993 View
ENSG00000126261 UBA2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.932737 View
ENSG00000070950 RAD18 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.932625 View
ENSG00000169032 MAP2K1 ENSG00000177889 UBE2N H. sapiens SSL Slorth 0.932531 View
ENSG00000169032 MAP2K1 ENSG00000188612 SUMO2 H. sapiens SDL Slorth 0.93249 View
ENSG00000168610 STAT3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.932287 View
ENSG00000121022 COPS5 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.932263 View
ENSG00000078140 UBE2K ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.932019 View
ENSG00000134982 APC ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.931968 View
ENSG00000096717 SIRT1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.93172 View
ENSG00000113721 PDGFRB ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.931661 View
ENSG00000001626 CFTR ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.931299 View
ENSG00000108424 KPNB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.931178 View
ENSG00000077782 FGFR1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.931062 View
ENSG00000108424 KPNB1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.931013 View
ENSG00000134057 CCNB1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.930863 View
ENSG00000134308 YWHAQ ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.930799 View
ENSG00000136238 RAC1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.930663 View
ENSG00000093009 CDC45 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.930498 View
ENSG00000132383 RPA1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.930271 View
ENSG00000137154 RPS6 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.930233 View
ENSG00000096384 HSP90AB1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.930081 View
ENSG00000169032 MAP2K1 ENSG00000196591 HDAC2 H. sapiens SDL Slorth 0.929676 View
ENSG00000064012 CASP8 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.929575 View
ENSG00000169032 MAP2K1 ENSG00000170606 HSPA4 H. sapiens SSL Slorth 0.929519 View
ENSG00000113721 PDGFRB ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.929426 View
ENSG00000071082 RPL31 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.929173 View
ENSG00000100519 PSMC6 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.928936 View
ENSG00000169032 MAP2K1 ENSG00000213281 NRAS H. sapiens SDL Slorth 0.928809 View
ENSG00000089159 PXN ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.928718 View
ENSG00000105810 CDK6 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.928564 View
ENSG00000041357 PSMA4 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.928431 View
ENSG00000140464 PML ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.928309 View
ENSG00000116473 RAP1A ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.928219 View
ENSG00000169032 MAP2K1 ENSG00000180900 SCRIB H. sapiens SDL Slorth 0.928085 View
ENSG00000141564 RPTOR ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.928021 View