MAP2K1

ENSG00000169032 - H. sapiens

Pathways

Go term Description
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma
colorectal

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000169032 MAP2K1 ENSG00000186575 NF2 H. sapiens SDL Slorth 0.90982 View
ENSG00000133703 KRAS ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.909754 View
ENSG00000106462 EZH2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.909451 View
ENSG00000004897 CDC27 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.909283 View
ENSG00000070831 CDC42 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.909245 View
ENSG00000130726 TRIM28 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.909132 View
ENSG00000126561 STAT5A ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.908991 View
ENSG00000141564 RPTOR ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.908917 View
ENSG00000169032 MAP2K1 ENSG00000198825 INPP5F H. sapiens SDL Slorth 0.90859 View
ENSG00000169032 MAP2K1 ENSG00000213923 CSNK1E H. sapiens SDL Slorth 0.908127 View
ENSG00000072062 PRKACA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.908078 View
ENSG00000078747 ITCH ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.908029 View
ENSG00000169032 MAP2K1 ENSG00000196923 PDLIM7 H. sapiens SDL Slorth 0.90796 View
ENSG00000121879 PIK3CA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.907231 View
ENSG00000166508 MCM7 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.9072 View
ENSG00000094804 CDC6 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.906974 View
ENSG00000169032 MAP2K1 ENSG00000173020 GRK2 H. sapiens SDL Slorth 0.90693 View
ENSG00000006451 RALA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.906877 View
ENSG00000023445 BIRC3 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.906847 View
ENSG00000169032 MAP2K1 ENSG00000170027 YWHAG H. sapiens SDL Slorth 0.906818 View
ENSG00000102978 POLR2C ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.906628 View
ENSG00000169032 MAP2K1 ENSG00000171791 BCL2 H. sapiens SSL Slorth 0.906579 View
ENSG00000168090 COPS6 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.906469 View
ENSG00000167513 CDT1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.90638 View
ENSG00000005007 UPF1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.905938 View
ENSG00000074319 TSG101 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.905472 View
ENSG00000145386 CCNA2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.905285 View
ENSG00000124614 RPS10 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.905205 View
ENSG00000136930 PSMB7 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.904907 View
ENSG00000116044 NFE2L2 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.904903 View
ENSG00000100906 NFKBIA ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.904578 View
ENSG00000169032 MAP2K1 ENSG00000221983 UBA52 H. sapiens SDL Slorth 0.904526 View
ENSG00000137486 ARRB1 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.904473 View
ENSG00000169032 MAP2K1 ENSG00000180176 TH H. sapiens SDL Slorth 0.904448 View
ENSG00000089157 RPLP0 ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.904439 View
ENSG00000061273 HDAC7 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.903724 View
ENSG00000095015 MAP3K1 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.9032 View
ENSG00000061938 TNK2 ENSG00000169032 MAP2K1 H. sapiens SSL Slorth 0.903058 View
ENSG00000169032 MAP2K1 ENSG00000169252 ADRB2 H. sapiens SDL Slorth 0.902884 View
ENSG00000128052 KDR ENSG00000169032 MAP2K1 H. sapiens SDL Slorth 0.902792 View