EPAS1 - MAP2K1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
EPAS1	ENSG00000116016	paraganglioma pheochromocytoma central nervous system hemangioblastomas	No drugs in record	RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding protein binding transcription factor binding histone acetyltransferase binding protein heterodimerization activity sequence-specific DNA binding	hif-1 (C. elegans)
MAP2K1	ENSG00000169032	NSCLC melanoma colorectal	TRAMETINIB	protein kinase activity protein serine/threonine kinase activity signal transducer, downstream of receptor, with serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine phosphatase activity protein binding ATP binding protein C-terminus binding protein kinase binding protein serine/threonine kinase activator activity protein N-terminus binding	PBS2 (S. cerevisiae) mek-2 (C. elegans) Dsor1 (D. melanogaster)