MAP2K1 - SMAD2

H. sapiens

SDL interaction

Identifiers

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
MAP2K1	ENSG00000169032	NSCLC melanoma colorectal	TRAMETINIB	protein kinase activity protein serine/threonine kinase activity signal transducer, downstream of receptor, with serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine phosphatase activity protein binding ATP binding protein C-terminus binding protein kinase binding protein serine/threonine kinase activator activity protein N-terminus binding	PBS2 (S. cerevisiae) mek-2 (C. elegans) Dsor1 (D. melanogaster)
SMAD2	ENSG00000175387	colorectal carcinoma hepatocellular carcinoma	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor binding protein binding transcription factor binding phosphatase binding transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ubiquitin protein ligase binding activating transcription factor binding type I transforming growth factor beta receptor binding enhancer binding protein homodimerization activity SMAD binding metal ion binding protein heterodimerization activity co-SMAD binding I-SMAD binding R-SMAD binding DNA binding	sma-3 (C. elegans) sma-2 (C. elegans)