PML - MAP2K1

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
PML	ENSG00000140464	APL ALL	No drugs in record	DNA binding protein binding zinc ion binding ubiquitin protein ligase binding SUMO binding protein homodimerization activity SMAD binding	No GO terms in record
MAP2K1	ENSG00000169032	NSCLC melanoma colorectal	TRAMETINIB	protein kinase activity protein serine/threonine kinase activity signal transducer, downstream of receptor, with serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine phosphatase activity protein binding ATP binding protein C-terminus binding protein kinase binding protein serine/threonine kinase activator activity protein N-terminus binding	PBS2 (S. cerevisiae) mek-2 (C. elegans) Dsor1 (D. melanogaster)