WRN

ENSG00000165392 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0000403 Y-form DNA binding
GO:0000405 bubble DNA binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008408 3'-5' exonuclease activity
GO:0009378 four-way junction helicase activity
GO:0016887 ATPase activity
GO:0030145 manganese ion binding
GO:0032403 protein complex binding
GO:0042803 protein homodimerization activity
GO:0043138 3'-5' DNA helicase activity
GO:0043140 ATP-dependent 3'-5' DNA helicase activity
GO:0051880 G-quadruplex DNA binding

Drugs

No drugs in record

Diseases

Disease Name
osteosarcoma
meningioma
other tumour types

Orthologs

Gene Organism
SGS1 S. cerevisiae
wrn-1 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000100239 PPP6R2 ENSG00000165392 WRN H. sapiens SDL Slorth 0.95202 View
ENSG00000165392 WRN ENSG00000181163 NPM1 H. sapiens SDL Slorth 0.951652 View
ENSG00000136628 EPRS ENSG00000165392 WRN H. sapiens SSL Slorth 0.951643 View
ENSG00000165392 WRN ENSG00000166508 MCM7 H. sapiens SSL Slorth 0.95157 View
ENSG00000163435 ELF3 ENSG00000165392 WRN H. sapiens SDL Slorth 0.951512 View
ENSG00000102683 SGCG ENSG00000165392 WRN H. sapiens SDL Slorth 0.951487 View
ENSG00000153944 MSI2 ENSG00000165392 WRN H. sapiens SDL Slorth 0.951479 View
ENSG00000165392 WRN ENSG00000169045 HNRNPH1 H. sapiens SSL Slorth 0.951441 View
ENSG00000131747 TOP2A ENSG00000165392 WRN H. sapiens SSL Slorth 0.951305 View
ENSG00000165392 WRN ENSG00000173039 RELA H. sapiens SSL Slorth 0.951193 View
ENSG00000108094 CUL2 ENSG00000165392 WRN H. sapiens SSL Slorth 0.95108 View
ENSG00000154582 TCEB1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.950928 View
ENSG00000136518 ACTL6A ENSG00000165392 WRN H. sapiens SSL Slorth 0.950676 View
ENSG00000145715 RASA1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.950461 View
ENSG00000119541 VPS4B ENSG00000165392 WRN H. sapiens SSL Slorth 0.950442 View
ENSG00000110031 LPXN ENSG00000165392 WRN H. sapiens SDL Slorth 0.950274 View
ENSG00000135341 MAP3K7 ENSG00000165392 WRN H. sapiens SSL Slorth 0.950221 View
ENSG00000102882 MAPK3 ENSG00000165392 WRN H. sapiens SSL Slorth 0.9502 View
ENSG00000165392 WRN ENSG00000170004 CHD3 H. sapiens SSL Slorth 0.950146 View
ENSG00000109320 NFKB1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.950095 View
ENSG00000127337 YEATS4 ENSG00000165392 WRN H. sapiens SSL Slorth 0.949941 View
ENSG00000101343 CRNKL1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.949861 View
ENSG00000055130 CUL1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.949825 View
ENSG00000165392 WRN ENSG00000167986 DDB1 H. sapiens SSL Slorth 0.949693 View
ENSG00000080824 HSP90AA1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.949556 View
ENSG00000100603 SNW1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.949474 View
ENSG00000107581 EIF3A ENSG00000165392 WRN H. sapiens SSL Slorth 0.94911 View
ENSG00000106355 LSM5 ENSG00000165392 WRN H. sapiens SSL Slorth 0.949015 View
ENSG00000165392 WRN ENSG00000185386 MAPK11 H. sapiens SDL Slorth 0.949013 View
ENSG00000121774 KHDRBS1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.949013 View
ENSG00000165392 WRN ENSG00000167085 PHB H. sapiens SSL Slorth 0.948992 View
ENSG00000142534 RPS11 ENSG00000165392 WRN H. sapiens SDL Slorth 0.948854 View
ENSG00000112679 DUSP22 ENSG00000165392 WRN H. sapiens SDL Slorth 0.948812 View
ENSG00000131747 TOP2A ENSG00000165392 WRN H. sapiens SDL Slorth 0.948744 View
ENSG00000124486 USP9X ENSG00000165392 WRN H. sapiens SSL Slorth 0.948544 View
ENSG00000165392 WRN ENSG00000166851 PLK1 H. sapiens SSL Slorth 0.94842 View
ENSG00000058729 RIOK2 ENSG00000165392 WRN H. sapiens SSL Slorth 0.948365 View
ENSG00000165392 WRN ENSG00000166483 WEE1 H. sapiens SSL Slorth 0.948195 View
ENSG00000124813 RUNX2 ENSG00000165392 WRN H. sapiens SSL Slorth 0.948028 View
ENSG00000142192 APP ENSG00000165392 WRN H. sapiens SSL Slorth 0.947744 View