WRN

ENSG00000165392 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0000403 Y-form DNA binding
GO:0000405 bubble DNA binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008408 3'-5' exonuclease activity
GO:0009378 four-way junction helicase activity
GO:0016887 ATPase activity
GO:0030145 manganese ion binding
GO:0032403 protein complex binding
GO:0042803 protein homodimerization activity
GO:0043138 3'-5' DNA helicase activity
GO:0043140 ATP-dependent 3'-5' DNA helicase activity
GO:0051880 G-quadruplex DNA binding

Drugs

No drugs in record

Diseases

Disease Name
osteosarcoma
meningioma
other tumour types

Orthologs

Gene Organism
SGS1 S. cerevisiae
wrn-1 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000165392 WRN ENSG00000213949 ITGA1 H. sapiens SDL Slorth 0.974401 View
ENSG00000165392 WRN ENSG00000189067 LITAF H. sapiens SDL Slorth 0.974356 View
ENSG00000137693 YAP1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.973877 View
ENSG00000136807 CDK9 ENSG00000165392 WRN H. sapiens SSL Slorth 0.973659 View
ENSG00000103194 USP10 ENSG00000165392 WRN H. sapiens SSL Slorth 0.973296 View
ENSG00000117399 CDC20 ENSG00000165392 WRN H. sapiens SSL Slorth 0.973003 View
ENSG00000108443 RPS6KB1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.972899 View
ENSG00000097007 ABL1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.972407 View
ENSG00000123374 CDK2 ENSG00000165392 WRN H. sapiens SDL Slorth 0.972331 View
ENSG00000135018 UBQLN1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.971862 View
ENSG00000089159 PXN ENSG00000165392 WRN H. sapiens SSL Slorth 0.971819 View
ENSG00000165392 WRN ENSG00000168496 FEN1 H. sapiens SDL Slorth 0.971773 View
ENSG00000094804 CDC6 ENSG00000165392 WRN H. sapiens SSL Slorth 0.971646 View
ENSG00000165392 WRN ENSG00000175376 EIF1AD H. sapiens SDL Slorth 0.971556 View
ENSG00000103275 UBE2I ENSG00000165392 WRN H. sapiens SDL Slorth 0.971321 View
ENSG00000165392 WRN ENSG00000169862 CTNND2 H. sapiens SDL Slorth 0.971217 View
ENSG00000134853 PDGFRA ENSG00000165392 WRN H. sapiens SSL Slorth 0.971108 View
ENSG00000123374 CDK2 ENSG00000165392 WRN H. sapiens SSL Slorth 0.971018 View
ENSG00000065559 MAP2K4 ENSG00000165392 WRN H. sapiens SSL Slorth 0.971001 View
ENSG00000109906 ZBTB16 ENSG00000165392 WRN H. sapiens SSL Slorth 0.97065 View
ENSG00000157764 BRAF ENSG00000165392 WRN H. sapiens SSL Slorth 0.970637 View
ENSG00000165392 WRN ENSG00000166477 LEO1 H. sapiens SDL Slorth 0.970158 View
ENSG00000142208 AKT1 ENSG00000165392 WRN H. sapiens SDL Slorth 0.969797 View
ENSG00000119048 UBE2B ENSG00000165392 WRN H. sapiens SSL Slorth 0.969581 View
ENSG00000145386 CCNA2 ENSG00000165392 WRN H. sapiens SSL Slorth 0.969522 View
ENSG00000109971 HSPA8 ENSG00000165392 WRN H. sapiens SSL Slorth 0.969412 View
ENSG00000101361 NOP56 ENSG00000165392 WRN H. sapiens SDL Slorth 0.969319 View
ENSG00000061273 HDAC7 ENSG00000165392 WRN H. sapiens SSL Slorth 0.969129 View
ENSG00000085511 MAP3K4 ENSG00000165392 WRN H. sapiens SSL Slorth 0.96902 View
ENSG00000004897 CDC27 ENSG00000165392 WRN H. sapiens SSL Slorth 0.969017 View
ENSG00000082898 XPO1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.968962 View
ENSG00000140992 PDPK1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.968857 View
ENSG00000165392 WRN ENSG00000175387 SMAD2 H. sapiens SSL Slorth 0.96867 View
ENSG00000097046 CDC7 ENSG00000165392 WRN H. sapiens SSL Slorth 0.968596 View
ENSG00000165392 WRN ENSG00000170345 FOS H. sapiens SSL Slorth 0.968513 View
ENSG00000134057 CCNB1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.968381 View
ENSG00000143799 PARP1 ENSG00000165392 WRN H. sapiens SSL Slorth 0.968374 View
ENSG00000140464 PML ENSG00000165392 WRN H. sapiens SSL Slorth 0.968181 View
ENSG00000162385 MAGOH ENSG00000165392 WRN H. sapiens SDL Slorth 0.968116 View
ENSG00000064012 CASP8 ENSG00000165392 WRN H. sapiens SSL Slorth 0.968082 View