TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000131747 TOP2A ENSG00000142168 SOD1 H. sapiens SDL Slorth 0.93797 View
ENSG00000055130 CUL1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.9379 View
ENSG00000131747 TOP2A ENSG00000163132 MSX1 H. sapiens SDL Slorth 0.937875 View
ENSG00000131747 TOP2A ENSG00000148400 NOTCH1 H. sapiens SSL Slorth 0.937739 View
ENSG00000131747 TOP2A ENSG00000188612 SUMO2 H. sapiens SDL Slorth 0.937678 View
ENSG00000114867 EIF4G1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.937551 View
ENSG00000131747 TOP2A ENSG00000182511 FES H. sapiens SDL Slorth 0.937498 View
ENSG00000131747 TOP2A ENSG00000143799 PARP1 H. sapiens SDL Slorth 0.93728 View
ENSG00000131747 TOP2A ENSG00000136504 KAT7 H. sapiens SDL Slorth 0.937201 View
ENSG00000114742 WDR48 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.936945 View
ENSG00000131747 TOP2A ENSG00000180353 HCLS1 H. sapiens SDL Slorth 0.936893 View
ENSG00000117222 RBBP5 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.936883 View
ENSG00000129691 ASH2L ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.936792 View
ENSG00000131747 TOP2A ENSG00000157540 DYRK1A H. sapiens SDL Slorth 0.936683 View
ENSG00000131747 TOP2A ENSG00000196235 SUPT5H H. sapiens SSL Slorth 0.936584 View
ENSG00000101811 CSTF2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.936497 View
ENSG00000120656 TAF12 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.936382 View
ENSG00000050820 BCAR1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.936375 View
ENSG00000125952 MAX ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.936249 View
ENSG00000131747 TOP2A ENSG00000166483 WEE1 H. sapiens SSL Slorth 0.936238 View
ENSG00000002016 RAD52 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.936137 View
ENSG00000064012 CASP8 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.936112 View
ENSG00000130726 TRIM28 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.935953 View
ENSG00000131747 TOP2A ENSG00000163947 ARHGEF3 H. sapiens SDL Slorth 0.935919 View
ENSG00000131747 TOP2A ENSG00000132849 PATJ H. sapiens SDL Slorth 0.935667 View
ENSG00000100906 NFKBIA ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.93563 View
ENSG00000131747 TOP2A ENSG00000168610 STAT3 H. sapiens SSL Slorth 0.935592 View
ENSG00000131747 TOP2A ENSG00000135486 HNRNPA1 H. sapiens SSL Slorth 0.935291 View
ENSG00000131747 TOP2A ENSG00000172071 EIF2AK3 H. sapiens SDL Slorth 0.935261 View
ENSG00000131747 TOP2A ENSG00000197299 BLM H. sapiens SDL Slorth 0.935084 View
ENSG00000044574 HSPA5 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.93502 View
ENSG00000100297 MCM5 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.934994 View
ENSG00000078043 PIAS2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.934915 View
ENSG00000114503 NCBP2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.934836 View
ENSG00000131747 TOP2A ENSG00000168421 RHOH H. sapiens SDL Slorth 0.934617 View
ENSG00000131747 TOP2A ENSG00000136573 BLK H. sapiens SDL Slorth 0.934455 View
ENSG00000131747 TOP2A ENSG00000145604 SKP2 H. sapiens SDL Slorth 0.934451 View
ENSG00000131747 TOP2A ENSG00000161547 SRSF2 H. sapiens SSL Slorth 0.934432 View
ENSG00000129993 CBFA2T3 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.934376 View
ENSG00000110395 CBL ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.934339 View