TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000131747 TOP2A ENSG00000182247 UBE2E2 H. sapiens SSL Slorth 0.763442 View
ENSG00000034152 MAP2K3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.76342 View
ENSG00000131747 TOP2A ENSG00000163840 DTX3L H. sapiens SSL Slorth 0.763236 View
ENSG00000131475 VPS25 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.763149 View
ENSG00000131747 TOP2A ENSG00000169967 MAP3K2 H. sapiens SSL Slorth 0.762749 View
ENSG00000131747 TOP2A ENSG00000159377 PSMB4 H. sapiens SSL Slorth 0.762292 View
ENSG00000108946 PRKAR1A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.762067 View
ENSG00000113643 RARS ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.76061 View
ENSG00000116604 MEF2D ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.76021 View
ENSG00000131747 TOP2A ENSG00000182979 MTA1 H. sapiens SSL Slorth 0.760194 View
ENSG00000131747 TOP2A ENSG00000136273 HUS1 H. sapiens SSL Slorth 0.75968 View
ENSG00000131747 TOP2A ENSG00000196305 IARS H. sapiens SSL Slorth 0.759364 View
ENSG00000054116 TRAPPC3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.759128 View
ENSG00000068654 POLR1A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.759056 View
ENSG00000100227 POLDIP3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.75864 View
ENSG00000072110 ACTN1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.758324 View
ENSG00000112282 MED23 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.758292 View
ENSG00000100554 ATP6V1D ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.758196 View
ENSG00000119487 MAPKAP1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.757586 View
ENSG00000131747 TOP2A ENSG00000161057 PSMC2 H. sapiens SSL Slorth 0.75748 View
ENSG00000131747 TOP2A ENSG00000155229 MMS19 H. sapiens SSL Slorth 0.757453 View
ENSG00000109189 USP46 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.756809 View
ENSG00000100804 PSMB5 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.756193 View
ENSG00000009335 UBE3C ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.756107 View
ENSG00000108344 PSMD3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.755347 View
ENSG00000102038 SMARCA1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.755209 View
ENSG00000131747 TOP2A ENSG00000170035 UBE2E3 H. sapiens SSL Slorth 0.754572 View
ENSG00000131747 TOP2A ENSG00000167670 CHAF1A H. sapiens SSL Slorth 0.754113 View
ENSG00000131747 TOP2A ENSG00000161960 EIF4A1 H. sapiens SSL Slorth 0.754083 View
ENSG00000112249 ASCC3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.753881 View
ENSG00000103549 RNF40 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.753595 View
ENSG00000101945 SUV39H1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.753492 View
ENSG00000113368 LMNB1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.752767 View
ENSG00000101557 USP14 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.75266 View
ENSG00000111642 CHD4 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.752128 View
ENSG00000104885 DOT1L ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.752023 View
ENSG00000131747 TOP2A ENSG00000165916 PSMC3 H. sapiens SSL Slorth 0.751948 View
ENSG00000131747 TOP2A ENSG00000147854 UHRF2 H. sapiens SSL Slorth 0.751854 View
ENSG00000122545 SEPT7 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.751625 View
ENSG00000131747 TOP2A ENSG00000145375 SPATA5 H. sapiens SSL Slorth 0.751339 View