TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000129084 PSMA1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.778552 View
ENSG00000043093 DCUN1D1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.778466 View
ENSG00000131747 TOP2A ENSG00000164104 HMGB2 H. sapiens SSL Slorth 0.778204 View
ENSG00000073282 TP63 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.777899 View
ENSG00000101421 CHMP4B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.777136 View
ENSG00000131747 TOP2A ENSG00000175595 ERCC4 H. sapiens SSL Slorth 0.776937 View
ENSG00000131747 TOP2A ENSG00000181788 SIAH2 H. sapiens SSL Slorth 0.776885 View
ENSG00000131747 TOP2A ENSG00000143106 PSMA5 H. sapiens SSL Slorth 0.776862 View
ENSG00000131747 TOP2A ENSG00000137055 PLAA H. sapiens SSL Slorth 0.775196 View
ENSG00000081189 MEF2C ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.775051 View
ENSG00000131747 TOP2A ENSG00000141564 RPTOR H. sapiens SSL Slorth 0.774322 View
ENSG00000131747 TOP2A ENSG00000167491 GATAD2A H. sapiens SSL Slorth 0.773298 View
ENSG00000131747 TOP2A ENSG00000134058 CDK7 H. sapiens SSL Slorth 0.773067 View
ENSG00000099381 SETD1A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.773011 View
ENSG00000102554 KLF5 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.772563 View
ENSG00000108587 GOSR1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.772393 View
ENSG00000105197 TIMM50 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.772061 View
ENSG00000049541 RFC2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.771675 View
ENSG00000079387 SENP1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.771279 View
ENSG00000077080 ACTL6B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.771187 View
ENSG00000131462 TUBG1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.771038 View
ENSG00000118515 SGK1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.77045 View
ENSG00000105402 NAPA ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.770336 View
ENSG00000105976 MET ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.770094 View
ENSG00000089685 BIRC5 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.769828 View
ENSG00000131747 TOP2A ENSG00000132326 PER2 H. sapiens SSL Slorth 0.769718 View
ENSG00000131747 TOP2A ENSG00000170606 HSPA4 H. sapiens SSL Slorth 0.76954 View
ENSG00000119912 IDE ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.76934 View
ENSG00000090376 IRAK3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.769183 View
ENSG00000077254 USP33 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.768593 View
ENSG00000108468 CBX1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.768231 View
ENSG00000020922 MRE11 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.768197 View
ENSG00000007168 PAFAH1B1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.768169 View
ENSG00000124193 SRSF6 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.767952 View
ENSG00000085733 CTTN ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.766767 View
ENSG00000118971 CCND2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.766479 View
ENSG00000088832 FKBP1A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.765883 View
ENSG00000131747 TOP2A ENSG00000175029 CTBP2 H. sapiens SSL Slorth 0.765008 View
ENSG00000131747 TOP2A ENSG00000137076 TLN1 H. sapiens SSL Slorth 0.764692 View
ENSG00000131747 TOP2A ENSG00000135100 HNF1A H. sapiens SSL Slorth 0.763978 View