TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000115053 NCL ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.852653 View
ENSG00000122728 TAF1L ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.852116 View
ENSG00000100351 GRAP2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.85187 View
ENSG00000123737 EXOSC9 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.850773 View
ENSG00000131747 TOP2A ENSG00000186716 BCR H. sapiens SSL Slorth 0.850488 View
ENSG00000019995 ZRANB1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.850403 View
ENSG00000065054 SLC9A3R2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.85034 View
ENSG00000131747 TOP2A ENSG00000168066 SF1 H. sapiens SSL Slorth 0.849652 View
ENSG00000131747 TOP2A ENSG00000163960 UBXN7 H. sapiens SSL Slorth 0.848328 View
ENSG00000131747 TOP2A ENSG00000171824 EXOSC10 H. sapiens SSL Slorth 0.847398 View
ENSG00000011304 PTBP1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.84726 View
ENSG00000092820 EZR ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.846797 View
ENSG00000131747 TOP2A ENSG00000134371 CDC73 H. sapiens SSL Slorth 0.846651 View
ENSG00000131747 TOP2A ENSG00000166200 COPS2 H. sapiens SSL Slorth 0.846215 View
ENSG00000117360 PRPF3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.845596 View
ENSG00000112640 PPP2R5D ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.845381 View
ENSG00000102981 PARD6A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.844909 View
ENSG00000075785 RAB7A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.84459 View
ENSG00000131747 TOP2A ENSG00000133794 ARNTL H. sapiens SSL Slorth 0.844423 View
ENSG00000131747 TOP2A ENSG00000144554 FANCD2 H. sapiens SSL Slorth 0.844009 View
ENSG00000131747 TOP2A ENSG00000150593 PDCD4 H. sapiens SSL Slorth 0.843755 View
ENSG00000131747 TOP2A ENSG00000166477 LEO1 H. sapiens SSL Slorth 0.843573 View
ENSG00000070061 IKBKAP ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.843469 View
ENSG00000131747 TOP2A ENSG00000137054 POLR1E H. sapiens SSL Slorth 0.841371 View
ENSG00000124422 USP22 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.841139 View
ENSG00000131747 TOP2A ENSG00000134899 ERCC5 H. sapiens SSL Slorth 0.839775 View
ENSG00000105258 POLR2I ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.839306 View
ENSG00000112578 BYSL ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.839205 View
ENSG00000131747 TOP2A ENSG00000168556 ING2 H. sapiens SSL Slorth 0.83828 View
ENSG00000096063 SRPK1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.838149 View
ENSG00000048052 HDAC9 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.837962 View
ENSG00000131747 TOP2A ENSG00000164032 H2AFZ H. sapiens SSL Slorth 0.837904 View
ENSG00000131747 TOP2A ENSG00000183735 TBK1 H. sapiens SSL Slorth 0.836933 View
ENSG00000131747 TOP2A ENSG00000276618 RAD17 H. sapiens SSL Slorth 0.836683 View
ENSG00000101361 NOP56 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.836608 View
ENSG00000131747 TOP2A ENSG00000164045 CDC25A H. sapiens SSL Slorth 0.836232 View
ENSG00000131747 TOP2A ENSG00000138346 DNA2 H. sapiens SSL Slorth 0.836108 View
ENSG00000115808 STRN ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.835834 View
ENSG00000113460 BRIX1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.835792 View
ENSG00000065548 ZC3H15 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.835784 View