TOP2A - DNA2

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TOP2A	ENSG00000131747	No diseases in record	DAUNORUBICIN DOXORUBICIN EPIRUBICIN ETOPOSIDE ETOPOSIDE PHOSPHATE IDARUBICIN MITOXANTRONE PODOFILOX TENIPOSIDE VALRUBICIN	magnesium ion binding DNA binding chromatin binding DNA topoisomerase type II (ATP-hydrolyzing) activity protein kinase C binding protein binding ATP binding protein C-terminus binding DNA-dependent ATPase activity drug binding DNA binding, bending enzyme binding protein homodimerization activity histone deacetylase binding ubiquitin binding protein heterodimerization activity	TOP2 (S. cerevisiae) cin-4 (C. elegans) top-2 (C. elegans)
DNA2	ENSG00000138346	No diseases in record	No drugs in record	DNA binding DNA helicase activity helicase activity nuclease activity protein binding ATP binding ATPase activity site-specific endodeoxyribonuclease activity, specific for altered base 5'-flap endonuclease activity 5'-3' DNA helicase activity single-stranded DNA-dependent ATPase activity metal ion binding 4 iron, 4 sulfur cluster binding catalytic activity ATP-dependent DNA helicase activity single-stranded DNA endodeoxyribonuclease activity nucleotide binding hydrolase activity iron-sulfur cluster binding chromatin binding 5' overhang single-stranded DNA endodeoxyribonuclease activity single-stranded DNA 5'-3' exodeoxyribonuclease activity	DNA2 (S. cerevisiae) dna-2 (C. elegans) CG2990 (D. melanogaster)