TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000131747 TOP2A ENSG00000141480 ARRB2 H. sapiens SSL Slorth 0.895736 View
ENSG00000131747 TOP2A ENSG00000170142 UBE2E1 H. sapiens SSL Slorth 0.895633 View
ENSG00000131747 TOP2A ENSG00000162367 TAL1 H. sapiens SSL Slorth 0.895334 View
ENSG00000118503 TNFAIP3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.895142 View
ENSG00000131747 TOP2A ENSG00000153487 ING1 H. sapiens SSL Slorth 0.895024 View
ENSG00000119335 SET ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.894745 View
ENSG00000088986 DYNLL1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.893205 View
ENSG00000131747 TOP2A ENSG00000166167 BTRC H. sapiens SSL Slorth 0.89301 View
ENSG00000080603 SRCAP ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.892214 View
ENSG00000131747 TOP2A ENSG00000166913 YWHAB H. sapiens SSL Slorth 0.891564 View
ENSG00000131747 TOP2A ENSG00000135341 MAP3K7 H. sapiens SSL Slorth 0.891475 View
ENSG00000131747 TOP2A ENSG00000142453 CARM1 H. sapiens SSL Slorth 0.891374 View
ENSG00000035403 VCL ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.891123 View
ENSG00000120438 TCP1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.890934 View
ENSG00000106211 HSPB1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.890787 View
ENSG00000112658 SRF ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.89078 View
ENSG00000131747 TOP2A ENSG00000143514 TP53BP2 H. sapiens SSL Slorth 0.890758 View
ENSG00000070756 PABPC1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.890479 View
ENSG00000131747 TOP2A ENSG00000162434 JAK1 H. sapiens SSL Slorth 0.890425 View
ENSG00000101336 HCK ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.890057 View
ENSG00000131747 TOP2A ENSG00000168439 STIP1 H. sapiens SSL Slorth 0.889679 View
ENSG00000111424 VDR ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.889542 View
ENSG00000131747 TOP2A ENSG00000169083 AR H. sapiens SSL Slorth 0.889493 View
ENSG00000111581 NUP107 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.889129 View
ENSG00000128052 KDR ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.889093 View
ENSG00000113013 HSPA9 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.888055 View
ENSG00000130811 EIF3G ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.887632 View
ENSG00000076984 MAP2K7 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.887246 View
ENSG00000131747 TOP2A ENSG00000169047 IRS1 H. sapiens SSL Slorth 0.886844 View
ENSG00000077097 TOP2B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.886534 View
ENSG00000107404 DVL1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.886177 View
ENSG00000131747 TOP2A ENSG00000162231 NXF1 H. sapiens SSL Slorth 0.885407 View
ENSG00000068305 MEF2A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.8854 View
ENSG00000120837 NFYB ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.884917 View
ENSG00000100201 DDX17 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.884855 View
ENSG00000101109 STK4 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.884678 View
ENSG00000073969 NSF ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.883572 View
ENSG00000131747 TOP2A ENSG00000187608 ISG15 H. sapiens SSL Slorth 0.88263 View
ENSG00000131747 TOP2A ENSG00000177084 POLE H. sapiens SSL Slorth 0.882551 View
ENSG00000124486 USP9X ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.88215 View