TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000035928 RFC1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.83461 View
ENSG00000119318 RAD23B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.83412 View
ENSG00000070831 CDC42 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.833795 View
ENSG00000125630 POLR1B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.833488 View
ENSG00000101460 MAP1LC3A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.833379 View
ENSG00000100138 SNU13 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.832458 View
ENSG00000130522 JUND ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.832109 View
ENSG00000131747 TOP2A ENSG00000161956 SENP3 H. sapiens SSL Slorth 0.831875 View
ENSG00000131747 TOP2A ENSG00000152818 UTRN H. sapiens SSL Slorth 0.831746 View
ENSG00000111859 NEDD9 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.831665 View
ENSG00000115694 STK25 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.830678 View
ENSG00000131747 TOP2A ENSG00000176890 TYMS H. sapiens SSL Slorth 0.829456 View
ENSG00000124164 VAPB ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.829292 View
ENSG00000131747 TOP2A ENSG00000141968 VAV1 H. sapiens SSL Slorth 0.829179 View
ENSG00000131747 TOP2A ENSG00000158828 PINK1 H. sapiens SSL Slorth 0.828842 View
ENSG00000089737 DDX24 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.828543 View
ENSG00000131747 TOP2A ENSG00000150753 CCT5 H. sapiens SSL Slorth 0.828315 View
ENSG00000131747 TOP2A ENSG00000184260 HIST2H2AC H. sapiens SSL Slorth 0.827837 View
ENSG00000121653 MAPK8IP1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.826814 View
ENSG00000131747 TOP2A ENSG00000148606 POLR3A H. sapiens SSL Slorth 0.826458 View
ENSG00000080608 PUM3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.824609 View
ENSG00000071051 NCK2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.823721 View
ENSG00000116062 MSH6 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.822645 View
ENSG00000131747 TOP2A ENSG00000166598 HSP90B1 H. sapiens SSL Slorth 0.822111 View
ENSG00000131747 TOP2A ENSG00000167552 TUBA1A H. sapiens SSL Slorth 0.821957 View
ENSG00000131747 TOP2A ENSG00000167005 NUDT21 H. sapiens SSL Slorth 0.819428 View
ENSG00000113722 CDX1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.819273 View
ENSG00000104969 SGTA ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.819219 View
ENSG00000131747 TOP2A ENSG00000198911 SREBF2 H. sapiens SSL Slorth 0.819071 View
ENSG00000131747 TOP2A ENSG00000197442 MAP3K5 H. sapiens SSL Slorth 0.818866 View
ENSG00000112576 CCND3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.817956 View
ENSG00000108384 RAD51C ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.816761 View
ENSG00000111641 NOP2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.816452 View
ENSG00000112081 SRSF3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.81561 View
ENSG00000123358 NR4A1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.815575 View
ENSG00000009413 REV3L ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.815299 View
ENSG00000131747 TOP2A ENSG00000188021 UBQLN2 H. sapiens SSL Slorth 0.815231 View
ENSG00000106105 GARS ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.814871 View
ENSG00000115946 PNO1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.814518 View
ENSG00000108510 MED13 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.814257 View