TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000123374 CDK2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.973495 View
ENSG00000097046 CDC7 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.972256 View
ENSG00000100030 MAPK1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.972252 View
ENSG00000109971 HSPA8 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.97182 View
ENSG00000100030 MAPK1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.971416 View
ENSG00000101868 POLA1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.971367 View
ENSG00000114166 KAT2B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.971337 View
ENSG00000103194 USP10 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.971295 View
ENSG00000103275 UBE2I ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.971263 View
ENSG00000117399 CDC20 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.971164 View
ENSG00000131747 TOP2A ENSG00000138756 BMP2K H. sapiens SDL Slorth 0.971125 View
ENSG00000124762 CDKN1A ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.970953 View
ENSG00000131747 TOP2A ENSG00000174738 NR1D2 H. sapiens SDL Slorth 0.970769 View
ENSG00000121774 KHDRBS1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.970685 View
ENSG00000119048 UBE2B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.970565 View
ENSG00000131747 TOP2A ENSG00000135723 FHOD1 H. sapiens SDL Slorth 0.97055 View
ENSG00000131747 TOP2A ENSG00000135829 DHX9 H. sapiens SDL Slorth 0.970479 View
ENSG00000131747 TOP2A ENSG00000143033 MTF2 H. sapiens SDL Slorth 0.970381 View
ENSG00000131747 TOP2A ENSG00000168036 CTNNB1 H. sapiens SDL Slorth 0.970328 View
ENSG00000128908 INO80 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.970083 View
ENSG00000131747 TOP2A ENSG00000169800 RBMY1F H. sapiens SDL Slorth 0.969985 View
ENSG00000131747 TOP2A ENSG00000155090 KLF10 H. sapiens SDL Slorth 0.969514 View
ENSG00000070950 RAD18 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.969322 View
ENSG00000065559 MAP2K4 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.969236 View
ENSG00000004897 CDC27 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.969208 View
ENSG00000131747 TOP2A ENSG00000187098 MITF H. sapiens SDL Slorth 0.969036 View
ENSG00000131747 TOP2A ENSG00000204103 MAFB H. sapiens SDL Slorth 0.968726 View
ENSG00000100644 HIF1A ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.968594 View
ENSG00000131747 TOP2A ENSG00000169083 AR H. sapiens SDL Slorth 0.968524 View
ENSG00000094804 CDC6 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.96816 View
ENSG00000073111 MCM2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.968134 View
ENSG00000111276 CDKN1B ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.967459 View
ENSG00000072401 UBE2D1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.967454 View
ENSG00000110330 BIRC2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.967252 View
ENSG00000077097 TOP2B ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.967175 View
ENSG00000124762 CDKN1A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.967062 View
ENSG00000110092 CCND1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.966853 View
ENSG00000087586 AURKA ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.966687 View
ENSG00000010810 FYN ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.966642 View
ENSG00000070010 UFD1L ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.966617 View