TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000078140 UBE2K ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.962203 View
ENSG00000131747 TOP2A ENSG00000149554 CHEK1 H. sapiens SSL Slorth 0.962032 View
ENSG00000079134 THOC1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.961982 View
ENSG00000131747 TOP2A ENSG00000172977 KAT5 H. sapiens SSL Slorth 0.961955 View
ENSG00000060069 CTDP1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.9619 View
ENSG00000101665 SMAD7 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.961784 View
ENSG00000131747 TOP2A ENSG00000177606 JUN H. sapiens SDL Slorth 0.961589 View
ENSG00000131747 TOP2A ENSG00000157601 MX1 H. sapiens SDL Slorth 0.961345 View
ENSG00000063244 U2AF2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.961319 View
ENSG00000131747 TOP2A ENSG00000178573 MAF H. sapiens SDL Slorth 0.961128 View
ENSG00000121481 RNF2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.961061 View
ENSG00000126261 UBA2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.961045 View
ENSG00000127022 CANX ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.960868 View
ENSG00000127445 PIN1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.960856 View
ENSG00000131747 TOP2A ENSG00000172531 PPP1CA H. sapiens SSL Slorth 0.960813 View
ENSG00000131747 TOP2A ENSG00000143476 DTL H. sapiens SDL Slorth 0.960751 View
ENSG00000131747 TOP2A ENSG00000172531 PPP1CA H. sapiens SDL Slorth 0.960637 View
ENSG00000047315 POLR2B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.96058 View
ENSG00000131747 TOP2A ENSG00000181163 NPM1 H. sapiens SDL Slorth 0.960562 View
ENSG00000131747 TOP2A ENSG00000184900 SUMO3 H. sapiens SDL Slorth 0.960539 View
ENSG00000075624 ACTB ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.96039 View
ENSG00000131747 TOP2A ENSG00000168453 HR H. sapiens SDL Slorth 0.960256 View
ENSG00000099817 POLR2E ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.959713 View
ENSG00000131747 TOP2A ENSG00000173404 INSM1 H. sapiens SDL Slorth 0.959592 View
ENSG00000131747 TOP2A ENSG00000154767 XPC H. sapiens SDL Slorth 0.959583 View
ENSG00000131747 TOP2A ENSG00000135446 CDK4 H. sapiens SSL Slorth 0.959554 View
ENSG00000131747 TOP2A ENSG00000137843 PAK6 H. sapiens SDL Slorth 0.959381 View
ENSG00000131747 TOP2A ENSG00000162889 MAPKAPK2 H. sapiens SDL Slorth 0.959307 View
ENSG00000131747 TOP2A ENSG00000176720 BOK H. sapiens SDL Slorth 0.959201 View
ENSG00000080815 PSEN1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.959132 View
ENSG00000131747 TOP2A ENSG00000141448 GATA6 H. sapiens SDL Slorth 0.959126 View
ENSG00000131747 TOP2A ENSG00000143420 ENSA H. sapiens SDL Slorth 0.959054 View
ENSG00000131747 TOP2A ENSG00000213949 ITGA1 H. sapiens SDL Slorth 0.959025 View
ENSG00000131747 TOP2A ENSG00000198517 MAFK H. sapiens SDL Slorth 0.95895 View
ENSG00000131747 TOP2A ENSG00000189067 LITAF H. sapiens SDL Slorth 0.95891 View
ENSG00000131747 TOP2A ENSG00000132170 PPARG H. sapiens SSL Slorth 0.958845 View
ENSG00000131747 TOP2A ENSG00000145386 CCNA2 H. sapiens SSL Slorth 0.958685 View
ENSG00000131747 TOP2A ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.958685 View
ENSG00000055332 EIF2AK2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.958605 View
ENSG00000102054 RBBP7 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.958576 View