TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000113721 PDGFRB ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.958508 View
ENSG00000097007 ABL1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.958347 View
ENSG00000131747 TOP2A ENSG00000175376 EIF1AD H. sapiens SDL Slorth 0.95832 View
ENSG00000092201 SUPT16H ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.958144 View
ENSG00000131747 TOP2A ENSG00000183207 RUVBL2 H. sapiens SSL Slorth 0.958107 View
ENSG00000131747 TOP2A ENSG00000170345 FOS H. sapiens SSL Slorth 0.957919 View
ENSG00000131747 TOP2A ENSG00000166477 LEO1 H. sapiens SDL Slorth 0.95786 View
ENSG00000105974 CAV1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.95782 View
ENSG00000093009 CDC45 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.957601 View
ENSG00000131747 TOP2A ENSG00000183791 TCEB3C H. sapiens SDL Slorth 0.957484 View
ENSG00000131747 TOP2A ENSG00000148516 ZEB1 H. sapiens SDL Slorth 0.95712 View
ENSG00000131747 TOP2A ENSG00000206181 TCEB3B H. sapiens SDL Slorth 0.9571 View
ENSG00000131747 TOP2A ENSG00000198838 RYR3 H. sapiens SDL Slorth 0.95693 View
ENSG00000131747 TOP2A ENSG00000159216 RUNX1 H. sapiens SSL Slorth 0.956836 View
ENSG00000131747 TOP2A ENSG00000170004 CHD3 H. sapiens SDL Slorth 0.956714 View
ENSG00000121022 COPS5 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.956696 View
ENSG00000069869 NEDD4 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.956529 View
ENSG00000131747 TOP2A ENSG00000155846 PPARGC1B H. sapiens SDL Slorth 0.956359 View
ENSG00000058729 RIOK2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.956353 View
ENSG00000131747 TOP2A ENSG00000177889 UBE2N H. sapiens SSL Slorth 0.956283 View
ENSG00000131747 TOP2A ENSG00000182968 SOX1 H. sapiens SDL Slorth 0.956222 View
ENSG00000118046 STK11 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.9561 View
ENSG00000131747 TOP2A ENSG00000168148 HIST3H3 H. sapiens SSL Slorth 0.955965 View
ENSG00000131508 UBE2D2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.955948 View
ENSG00000105568 PPP2R1A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.955794 View
ENSG00000131747 TOP2A ENSG00000141646 SMAD4 H. sapiens SSL Slorth 0.955667 View
ENSG00000131747 TOP2A ENSG00000137825 ITPKA H. sapiens SDL Slorth 0.955615 View
ENSG00000131747 TOP2A ENSG00000256223 ZNF10 H. sapiens SDL Slorth 0.955542 View
ENSG00000131747 TOP2A ENSG00000165409 TSHR H. sapiens SDL Slorth 0.955357 View
ENSG00000131747 TOP2A ENSG00000205629 LCMT1 H. sapiens SDL Slorth 0.955256 View
ENSG00000131747 TOP2A ENSG00000184470 TXNRD2 H. sapiens SDL Slorth 0.955244 View
ENSG00000131747 TOP2A ENSG00000160224 AIRE H. sapiens SDL Slorth 0.955207 View
ENSG00000131747 TOP2A ENSG00000145604 SKP2 H. sapiens SSL Slorth 0.955081 View
ENSG00000131747 TOP2A ENSG00000185697 MYBL1 H. sapiens SDL Slorth 0.955011 View
ENSG00000131747 TOP2A ENSG00000170365 SMAD1 H. sapiens SSL Slorth 0.95499 View
ENSG00000089159 PXN ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.9549 View
ENSG00000130939 UBE4B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.954824 View
ENSG00000131747 TOP2A ENSG00000165671 NSD1 H. sapiens SDL Slorth 0.954711 View
ENSG00000131747 TOP2A ENSG00000188486 H2AFX H. sapiens SSL Slorth 0.954695 View
ENSG00000072062 PRKACA ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.954685 View