TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000055130 CUL1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.918776 View
ENSG00000131747 TOP2A ENSG00000132781 MUTYH H. sapiens SDL Slorth 0.91876 View
ENSG00000131747 TOP2A ENSG00000152669 CCNO H. sapiens SDL Slorth 0.918697 View
ENSG00000126561 STAT5A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.918688 View
ENSG00000095002 MSH2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.918576 View
ENSG00000131747 TOP2A ENSG00000169372 CRADD H. sapiens SDL Slorth 0.918237 View
ENSG00000050748 MAPK9 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.918127 View
ENSG00000131747 TOP2A ENSG00000143190 POU2F1 H. sapiens SSL Slorth 0.918089 View
ENSG00000131747 TOP2A ENSG00000205250 E2F4 H. sapiens SDL Slorth 0.917915 View
ENSG00000131747 TOP2A ENSG00000169696 ASPSCR1 H. sapiens SDL Slorth 0.917878 View
ENSG00000110713 NUP98 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.917727 View
ENSG00000072803 FBXW11 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.91764 View
ENSG00000131747 TOP2A ENSG00000184634 MED12 H. sapiens SDL Slorth 0.917531 View
ENSG00000074266 EED ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.917395 View
ENSG00000131747 TOP2A ENSG00000169375 SIN3A H. sapiens SDL Slorth 0.917185 View
ENSG00000131747 TOP2A ENSG00000157933 SKI H. sapiens SDL Slorth 0.917151 View
ENSG00000131747 TOP2A ENSG00000137154 RPS6 H. sapiens SDL Slorth 0.91713 View
ENSG00000131747 TOP2A ENSG00000170836 PPM1D H. sapiens SDL Slorth 0.916942 View
ENSG00000100029 PES1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.916912 View
ENSG00000131747 TOP2A ENSG00000168283 BMI1 H. sapiens SDL Slorth 0.916799 View
ENSG00000131747 TOP2A ENSG00000146648 EGFR H. sapiens SDL Slorth 0.916294 View
ENSG00000131747 TOP2A ENSG00000188612 SUMO2 H. sapiens SSL Slorth 0.916025 View
ENSG00000131747 TOP2A ENSG00000139842 CUL4A H. sapiens SSL Slorth 0.915958 View
ENSG00000131747 TOP2A ENSG00000172534 HCFC1 H. sapiens SSL Slorth 0.915946 View
ENSG00000051382 PIK3CB ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.915844 View
ENSG00000131747 TOP2A ENSG00000169375 SIN3A H. sapiens SSL Slorth 0.915797 View
ENSG00000131747 TOP2A ENSG00000185591 SP1 H. sapiens SDL Slorth 0.915616 View
ENSG00000131747 TOP2A ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.915247 View
ENSG00000131747 TOP2A ENSG00000147140 NONO H. sapiens SDL Slorth 0.915227 View
ENSG00000131747 TOP2A ENSG00000203879 GDI1 H. sapiens SDL Slorth 0.915202 View
ENSG00000080503 SMARCA2 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.915117 View
ENSG00000131747 TOP2A ENSG00000135476 ESPL1 H. sapiens SDL Slorth 0.915 View
ENSG00000117133 RPF1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.914796 View
ENSG00000131747 TOP2A ENSG00000172939 OXSR1 H. sapiens SDL Slorth 0.914609 View
ENSG00000131747 TOP2A ENSG00000204389 HSPA1A H. sapiens SDL Slorth 0.914466 View
ENSG00000131747 TOP2A ENSG00000164924 YWHAZ H. sapiens SSL Slorth 0.91375 View
ENSG00000131747 TOP2A ENSG00000166341 DCHS1 H. sapiens SDL Slorth 0.913474 View
ENSG00000117399 CDC20 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.913244 View
ENSG00000131747 TOP2A ENSG00000214102 WEE2 H. sapiens SDL Slorth 0.913029 View
ENSG00000131747 TOP2A ENSG00000204390 HSPA1L H. sapiens SDL Slorth 0.913029 View