TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000105011 ASF1B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.934295 View
ENSG00000131747 TOP2A ENSG00000154997 SEPT14 H. sapiens SDL Slorth 0.934055 View
ENSG00000131747 TOP2A ENSG00000178999 AURKB H. sapiens SDL Slorth 0.934021 View
ENSG00000118007 STAG1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.934009 View
ENSG00000131747 TOP2A ENSG00000174405 LIG4 H. sapiens SDL Slorth 0.933994 View
ENSG00000131747 TOP2A ENSG00000141027 NCOR1 H. sapiens SSL Slorth 0.933924 View
ENSG00000116044 NFE2L2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.933779 View
ENSG00000026103 FAS ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.933742 View
ENSG00000131747 TOP2A ENSG00000147274 RBMX H. sapiens SSL Slorth 0.933673 View
ENSG00000131747 TOP2A ENSG00000166851 PLK1 H. sapiens SDL Slorth 0.933517 View
ENSG00000131747 TOP2A ENSG00000141738 GRB7 H. sapiens SDL Slorth 0.933461 View
ENSG00000131747 TOP2A ENSG00000165416 SUGT1 H. sapiens SSL Slorth 0.933447 View
ENSG00000131747 TOP2A ENSG00000181449 SOX2 H. sapiens SDL Slorth 0.932905 View
ENSG00000130177 CDC16 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.932817 View
ENSG00000110107 PRPF19 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.932628 View
ENSG00000131747 TOP2A ENSG00000147162 OGT H. sapiens SSL Slorth 0.932626 View
ENSG00000110048 OSBP ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.932542 View
ENSG00000131747 TOP2A ENSG00000157933 SKI H. sapiens SSL Slorth 0.932457 View
ENSG00000131747 TOP2A ENSG00000170004 CHD3 H. sapiens SSL Slorth 0.932425 View
ENSG00000131747 TOP2A ENSG00000163904 SENP2 H. sapiens SDL Slorth 0.932378 View
ENSG00000131747 TOP2A ENSG00000140600 SH3GL3 H. sapiens SDL Slorth 0.932356 View
ENSG00000113712 CSNK1A1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.932253 View
ENSG00000131747 TOP2A ENSG00000166407 LMO1 H. sapiens SDL Slorth 0.932232 View
ENSG00000090372 STRN4 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.932108 View
ENSG00000131747 TOP2A ENSG00000167085 PHB H. sapiens SSL Slorth 0.931955 View
ENSG00000131747 TOP2A ENSG00000164362 TERT H. sapiens SDL Slorth 0.931767 View
ENSG00000131747 TOP2A ENSG00000169813 HNRNPF H. sapiens SSL Slorth 0.931649 View
ENSG00000131747 TOP2A ENSG00000141582 CBX4 H. sapiens SDL Slorth 0.931607 View
ENSG00000131747 TOP2A ENSG00000135597 REPS1 H. sapiens SDL Slorth 0.931585 View
ENSG00000130699 TAF4 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.931568 View
ENSG00000096384 HSP90AB1 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.931489 View
ENSG00000131747 TOP2A ENSG00000137486 ARRB1 H. sapiens SDL Slorth 0.931118 View
ENSG00000131747 TOP2A ENSG00000170315 UBB H. sapiens SDL Slorth 0.930956 View
ENSG00000100142 POLR2F ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.93094 View
ENSG00000131747 TOP2A ENSG00000154310 TNIK H. sapiens SDL Slorth 0.930883 View
ENSG00000131747 TOP2A ENSG00000198625 MDM4 H. sapiens SSL Slorth 0.930865 View
ENSG00000122406 RPL5 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.93049 View
ENSG00000131747 TOP2A ENSG00000185513 L3MBTL1 H. sapiens SDL Slorth 0.930283 View
ENSG00000131747 TOP2A ENSG00000187735 TCEA1 H. sapiens SSL Slorth 0.930232 View
ENSG00000131747 TOP2A ENSG00000136997 MYC H. sapiens SSL Slorth 0.930138 View