TOP2A

ENSG00000131747 - H. sapiens

Pathways

Go term Description
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0046982 protein heterodimerization activity

Drugs

Drug name Description
DAUNORUBICIN DNA topoisomerase II alpha inhibitor
DOXORUBICIN DNA topoisomerase II alpha inhibitor
EPIRUBICIN
ETOPOSIDE DNA topoisomerase II inhibitor
ETOPOSIDE PHOSPHATE DNA topoisomerase II alpha inhibitor
IDARUBICIN DNA topoisomerase II alpha inhibitor
MITOXANTRONE
PODOFILOX
TENIPOSIDE DNA topoisomerase II inhibitor
VALRUBICIN DNA topoisomerase II alpha inhibitor

Diseases

No diseases in record

Orthologs

Gene Organism
TOP2 S. cerevisiae
cin-4 C. elegans
top-2 C. elegans

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000104375 STK3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.929968 View
ENSG00000103197 TSC2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.929858 View
ENSG00000094880 CDC23 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.929714 View
ENSG00000101966 XIAP ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.929697 View
ENSG00000001167 NFYA ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.929269 View
ENSG00000131747 TOP2A ENSG00000198742 SMURF1 H. sapiens SSL Slorth 0.929007 View
ENSG00000102572 STK24 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.928985 View
ENSG00000131747 TOP2A ENSG00000143476 DTL H. sapiens SSL Slorth 0.928939 View
ENSG00000106263 EIF3B ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.928836 View
ENSG00000051180 RAD51 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.928796 View
ENSG00000131747 TOP2A ENSG00000168496 FEN1 H. sapiens SDL Slorth 0.9285 View
ENSG00000076242 MLH1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.928389 View
ENSG00000121879 PIK3CA ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.928372 View
ENSG00000131747 TOP2A ENSG00000145632 PLK2 H. sapiens SDL Slorth 0.928348 View
ENSG00000101665 SMAD7 ENSG00000131747 TOP2A H. sapiens SDL Slorth 0.92814 View
ENSG00000116478 HDAC1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.928085 View
ENSG00000006451 RALA ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.928043 View
ENSG00000066468 FGFR2 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.928015 View
ENSG00000064995 TAF11 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.927584 View
ENSG00000131747 TOP2A ENSG00000148843 PDCD11 H. sapiens SDL Slorth 0.92753 View
ENSG00000131747 TOP2A ENSG00000166483 WEE1 H. sapiens SDL Slorth 0.927443 View
ENSG00000085511 MAP3K4 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.926897 View
ENSG00000131747 TOP2A ENSG00000136237 RAPGEF5 H. sapiens SDL Slorth 0.926731 View
ENSG00000118689 FOXO3 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.926694 View
ENSG00000131747 TOP2A ENSG00000213341 CHUK H. sapiens SSL Slorth 0.926368 View
ENSG00000131747 TOP2A ENSG00000169139 UBE2V2 H. sapiens SSL Slorth 0.926268 View
ENSG00000131747 TOP2A ENSG00000164885 CDK5 H. sapiens SSL Slorth 0.926167 View
ENSG00000126457 PRMT1 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.926001 View
ENSG00000094916 CBX5 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.925753 View
ENSG00000131747 TOP2A ENSG00000170312 CDK1 H. sapiens SSL Slorth 0.925739 View
ENSG00000117713 ARID1A ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.925685 View
ENSG00000131747 TOP2A ENSG00000177606 JUN H. sapiens SSL Slorth 0.924622 View
ENSG00000131747 TOP2A ENSG00000175643 RMI2 H. sapiens SDL Slorth 0.92411 View
ENSG00000106245 BUD31 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.924081 View
ENSG00000131747 TOP2A ENSG00000157514 TSC22D3 H. sapiens SDL Slorth 0.923885 View
ENSG00000131747 TOP2A ENSG00000149311 ATM H. sapiens SDL Slorth 0.923714 View
ENSG00000131747 TOP2A ENSG00000168646 AXIN2 H. sapiens SDL Slorth 0.923407 View
ENSG00000068024 HDAC4 ENSG00000131747 TOP2A H. sapiens SSL Slorth 0.923253 View
ENSG00000131747 TOP2A ENSG00000169891 REPS2 H. sapiens SDL Slorth 0.923139 View
ENSG00000131747 TOP2A ENSG00000136021 SCYL2 H. sapiens SDL Slorth 0.923131 View