DOT1L - TOP2A

H. sapiens

SSL interaction

Identifiers

Gene Name Gene ID Diseases Drugs GO terms Orthologs
DOT1L ENSG00000104885

No diseases in record

No drugs in record

DNA binding
protein binding
histone-lysine N-methyltransferase activity
histone methyltransferase activity (H3-K79 specific)
histone methyltransferase activity
DOT1 (S. cerevisiae)
gpp (D. melanogaster)
TOP2A ENSG00000131747

No diseases in record

DAUNORUBICIN
DOXORUBICIN
EPIRUBICIN
ETOPOSIDE
ETOPOSIDE PHOSPHATE
IDARUBICIN
MITOXANTRONE
PODOFILOX
TENIPOSIDE
VALRUBICIN
magnesium ion binding
DNA binding
chromatin binding
DNA topoisomerase type II (ATP-hydrolyzing) activity
protein kinase C binding
protein binding
ATP binding
protein C-terminus binding
DNA-dependent ATPase activity
drug binding
DNA binding, bending
enzyme binding
protein homodimerization activity
histone deacetylase binding
ubiquitin binding
protein heterodimerization activity
TOP2 (S. cerevisiae)
cin-4 (C. elegans)
top-2 (C. elegans)