TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000101665 SMAD7 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.933827 View
ENSG00000148308 GTF3C5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.933566 View
ENSG00000198677 TTC37 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.93351 View
ENSG00000152086 TUBA3E ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.933467 View
ENSG00000101336 HCK ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.933467 View
ENSG00000123737 EXOSC9 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.933442 View
ENSG00000106263 EIF3B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.933429 View
ENSG00000100138 SNU13 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.93338 View
ENSG00000108384 RAD51C ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.933107 View
ENSG00000111596 CNOT2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.93306 View
ENSG00000153250 RBMS1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.932935 View
ENSG00000142655 PEX14 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.932871 View
ENSG00000074181 NOTCH3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.932716 View
ENSG00000163558 PRKCI ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.93263 View
ENSG00000165416 SUGT1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.93262 View
ENSG00000076555 ACACB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.932377 View
ENSG00000172531 PPP1CA ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.932351 View
ENSG00000124813 RUNX2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.932307 View
ENSG00000151090 THRB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.932186 View
ENSG00000058729 RIOK2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.932064 View
ENSG00000067225 PKM ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.932054 View
ENSG00000010017 RANBP9 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.932031 View
ENSG00000170144 HNRNPA3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.931843 View
ENSG00000051382 PIK3CB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.931738 View
ENSG00000181163 NPM1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.931009 View
ENSG00000111602 TIMELESS ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.930284 View
ENSG00000130713 EXOSC2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.930102 View
ENSG00000150753 CCT5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.930022 View
ENSG00000162924 REL ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.92998 View
ENSG00000136100 VPS36 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.929824 View
ENSG00000103479 RBL2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.929572 View
ENSG00000196262 PPIA ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.929565 View
ENSG00000168090 COPS6 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.929526 View
ENSG00000130726 TRIM28 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.929239 View
ENSG00000104907 TRMT1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.929149 View
ENSG00000085840 ORC1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.929092 View
ENSG00000100297 MCM5 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.929041 View
ENSG00000198087 CD2AP ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.929005 View
ENSG00000130479 MAP1S ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.928841 View
ENSG00000034152 MAP2K3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.928764 View