TOP1

ENSG00000198900 - H. sapiens

Pathways

Go term Description
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0003916 DNA topoisomerase activity

Drugs

Drug name Description
IRINOTECAN DNA topoisomerase I inhibitor

Diseases

Disease Name
AML*

Orthologs

Gene Organism
TOP1 S. cerevisiae
top-1 C. elegans
Top1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000148688 RPP30 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.928747 View
ENSG00000172757 CFL1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.928728 View
ENSG00000135766 EGLN1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.928706 View
ENSG00000196419 XRCC6 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.928527 View
ENSG00000133794 ARNTL ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.928198 View
ENSG00000184634 MED12 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.928195 View
ENSG00000108590 MED31 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.928099 View
ENSG00000118971 CCND2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.928026 View
ENSG00000127955 GNAI1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.927863 View
ENSG00000174371 EXO1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.927744 View
ENSG00000101343 CRNKL1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.92765 View
ENSG00000055130 CUL1 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.927532 View
ENSG00000101057 MYBL2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.927472 View
ENSG00000133119 RFC3 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.927451 View
ENSG00000169398 PTK2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.927329 View
ENSG00000064012 CASP8 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.927317 View
ENSG00000136450 SRSF1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.927282 View
ENSG00000196470 SIAH1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.927232 View
ENSG00000177084 POLE ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.927082 View
ENSG00000076604 TRAF4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.927057 View
ENSG00000128739 SNRPN ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.926962 View
ENSG00000114867 EIF4G1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.926918 View
ENSG00000154229 PRKCA ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.926904 View
ENSG00000196586 MYO6 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.926223 View
ENSG00000073969 NSF ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.926137 View
ENSG00000104365 IKBKB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.926099 View
ENSG00000134001 EIF2S1 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.926058 View
ENSG00000184428 TOP1MT ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.926042 View
ENSG00000078043 PIAS2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.92604 View
ENSG00000111276 CDKN1B ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.925949 View
ENSG00000184634 MED12 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.925928 View
ENSG00000105258 POLR2I ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.925876 View
ENSG00000101109 STK4 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.925835 View
ENSG00000061938 TNK2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.925692 View
ENSG00000093009 CDC45 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.925669 View
ENSG00000114166 KAT2B ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.92551 View
ENSG00000124171 PARD6B ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.925268 View
ENSG00000104695 PPP2CB ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.92506 View
ENSG00000153147 SMARCA5 ENSG00000198900 TOP1 H. sapiens SDL Slorth 0.92491 View
ENSG00000100351 GRAP2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.92487 View