CUL3 - TOP1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
CUL3	ENSG00000036257	lung cancer	No drugs in record	protein binding cyclin binding POZ domain binding ubiquitin protein ligase binding protein homodimerization activity protein heterodimerization activity ubiquitin-protein transferase activity ubiquitin protein ligase activity	CDC53 (S. cerevisiae) Cul3 (D. melanogaster)
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)