MAP2K2

ENSG00000126934 - H. sapiens

Pathways

Go term Description
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0030165 PDZ domain binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0046872 metal ion binding
GO:0097110 scaffold protein binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000105220 GPI ENSG00000126934 MAP2K2 H. sapiens SSL BioGRID 1.0 View
ENSG00000141068 KSR1 ENSG00000126934 MAP2K2 H. sapiens SSL BioGRID 1.0 View
ENSG00000126934 MAP2K2 ENSG00000051382 PIK3CB H. sapiens SSL BioGRID 1.0 View
ENSG00000126934 MAP2K2 ENSG00000141744 PNMT H. sapiens SSL BioGRID 1.0 View
ENSG00000126934 MAP2K2 ENSG00000128311 TST H. sapiens SSL BioGRID 1.0 View
ENSG00000142453 CARM1 ENSG00000126934 MAP2K2 H. sapiens SSL BioGRID 1.0 View
ENSG00000103653 CSK ENSG00000126934 MAP2K2 H. sapiens SSL BioGRID 1.0 View
ENSG00000126934 MAP2K2 ENSG00000136997 MYC H. sapiens SDL Slorth 0.989073 View
ENSG00000012048 BRCA1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.988617 View
ENSG00000005339 CREBBP ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.988237 View
ENSG00000126934 MAP2K2 ENSG00000177606 JUN H. sapiens SDL Slorth 0.987475 View
ENSG00000126934 MAP2K2 ENSG00000170315 UBB H. sapiens SDL Slorth 0.987109 View
ENSG00000091831 ESR1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.985692 View
ENSG00000126934 MAP2K2 ENSG00000169083 AR H. sapiens SDL Slorth 0.984657 View
ENSG00000116478 HDAC1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.983205 View
ENSG00000126934 MAP2K2 ENSG00000166949 SMAD3 H. sapiens SDL Slorth 0.983047 View
ENSG00000100030 MAPK1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.982108 View
ENSG00000126934 MAP2K2 ENSG00000132646 PCNA H. sapiens SDL Slorth 0.981988 View
ENSG00000123374 CDK2 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.981641 View
ENSG00000126934 MAP2K2 ENSG00000140464 PML H. sapiens SDL Slorth 0.980857 View
ENSG00000126934 MAP2K2 ENSG00000168610 STAT3 H. sapiens SDL Slorth 0.980623 View
ENSG00000126934 MAP2K2 ENSG00000173039 RELA H. sapiens SDL Slorth 0.979822 View
ENSG00000100393 EP300 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.979626 View
ENSG00000126934 MAP2K2 ENSG00000150991 UBC H. sapiens SDL Slorth 0.979236 View
ENSG00000100644 HIF1A ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.979139 View
ENSG00000109670 FBXW7 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.978542 View
ENSG00000124762 CDKN1A ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.978428 View
ENSG00000126934 MAP2K2 ENSG00000139687 RB1 H. sapiens SDL Slorth 0.977886 View
ENSG00000113558 SKP1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.977311 View
ENSG00000126934 MAP2K2 ENSG00000142208 AKT1 H. sapiens SDL Slorth 0.977011 View
ENSG00000126934 MAP2K2 ENSG00000196591 HDAC2 H. sapiens SDL Slorth 0.976633 View
ENSG00000126934 MAP2K2 ENSG00000168036 CTNNB1 H. sapiens SDL Slorth 0.976307 View
ENSG00000126934 MAP2K2 ENSG00000188612 SUMO2 H. sapiens SDL Slorth 0.976016 View
ENSG00000126934 MAP2K2 ENSG00000177885 GRB2 H. sapiens SDL Slorth 0.975153 View
ENSG00000126934 MAP2K2 ENSG00000133703 KRAS H. sapiens SSL Slorth 0.974838 View
ENSG00000126934 MAP2K2 ENSG00000141510 TP53 H. sapiens SDL Slorth 0.974219 View
ENSG00000103275 UBE2I ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.973801 View
ENSG00000126934 MAP2K2 ENSG00000197122 SRC H. sapiens SDL Slorth 0.972215 View
ENSG00000110395 CBL ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.971794 View
ENSG00000041357 PSMA4 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.971631 View