MAP2K2

ENSG00000126934 - H. sapiens

Pathways

Go term Description
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0030165 PDZ domain binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0046872 metal ion binding
GO:0097110 scaffold protein binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000126934 MAP2K2 ENSG00000128052 KDR H. sapiens SSL Slorth 0.806202 View
ENSG00000115524 SF3B1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.805416 View
ENSG00000126934 MAP2K2 ENSG00000154229 PRKCA H. sapiens SSL Slorth 0.805246 View
ENSG00000126934 MAP2K2 ENSG00000196470 SIAH1 H. sapiens SSL Slorth 0.803213 View
ENSG00000126934 MAP2K2 ENSG00000150093 ITGB1 H. sapiens SSL Slorth 0.797657 View
ENSG00000084774 CAD ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.795345 View
ENSG00000119048 UBE2B ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.795163 View
ENSG00000085832 EPS15 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.795037 View
ENSG00000099817 POLR2E ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.791352 View
ENSG00000103126 AXIN1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.790988 View
ENSG00000126934 MAP2K2 ENSG00000165416 SUGT1 H. sapiens SSL Slorth 0.789417 View
ENSG00000126934 MAP2K2 ENSG00000147010 SH3KBP1 H. sapiens SSL Slorth 0.789244 View
ENSG00000126934 MAP2K2 ENSG00000150459 SAP18 H. sapiens SSL Slorth 0.788461 View
ENSG00000126934 MAP2K2 ENSG00000141968 VAV1 H. sapiens SSL Slorth 0.787685 View
ENSG00000116288 PARK7 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.787219 View
ENSG00000104695 PPP2CB ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.786303 View
ENSG00000126934 MAP2K2 ENSG00000156970 BUB1B H. sapiens SSL Slorth 0.785836 View
ENSG00000126934 MAP2K2 ENSG00000145386 CCNA2 H. sapiens SSL Slorth 0.783845 View
ENSG00000126934 MAP2K2 ENSG00000172531 PPP1CA H. sapiens SSL Slorth 0.783753 View
ENSG00000115816 CEBPZ ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.782177 View
ENSG00000072803 FBXW11 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.780835 View
ENSG00000126934 MAP2K2 ENSG00000170027 YWHAG H. sapiens SSL Slorth 0.78001 View
ENSG00000126934 MAP2K2 ENSG00000127022 CANX H. sapiens SSL Slorth 0.778904 View
ENSG00000085840 ORC1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.778384 View
ENSG00000126934 MAP2K2 ENSG00000157764 BRAF H. sapiens SSL Slorth 0.778053 View
ENSG00000126934 MAP2K2 ENSG00000168496 FEN1 H. sapiens SSL Slorth 0.776402 View
ENSG00000126934 MAP2K2 ENSG00000141480 ARRB2 H. sapiens SSL Slorth 0.775352 View
ENSG00000110330 BIRC2 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.77491 View
ENSG00000126934 MAP2K2 ENSG00000186868 MAPT H. sapiens SSL Slorth 0.773835 View
ENSG00000126934 MAP2K2 ENSG00000198793 MTOR H. sapiens SSL Slorth 0.773732 View
ENSG00000126934 MAP2K2 ENSG00000132170 PPARG H. sapiens SSL Slorth 0.773527 View
ENSG00000102882 MAPK3 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.769468 View
ENSG00000126934 MAP2K2 ENSG00000140443 IGF1R H. sapiens SSL Slorth 0.769278 View
ENSG00000114503 NCBP2 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.768876 View
ENSG00000114062 UBE3A ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.766452 View
ENSG00000126934 MAP2K2 ENSG00000149311 ATM H. sapiens SSL Slorth 0.765738 View
ENSG00000116478 HDAC1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.765263 View
ENSG00000064012 CASP8 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.764974 View
ENSG00000126934 MAP2K2 ENSG00000141736 ERBB2 H. sapiens SSL Slorth 0.76488 View
ENSG00000108953 YWHAE ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.764294 View