MAP2K2

ENSG00000126934 - H. sapiens

Pathways

Go term Description
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0030165 PDZ domain binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0046872 metal ion binding
GO:0097110 scaffold protein binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000126067 PSMB2 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.951006 View
ENSG00000087191 PSMC5 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.950746 View
ENSG00000072401 UBE2D1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.949769 View
ENSG00000115524 SF3B1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.949549 View
ENSG00000110395 CBL ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.948878 View
ENSG00000109320 NFKB1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.948164 View
ENSG00000101868 POLA1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.947221 View
ENSG00000113575 PPP2CA ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.947211 View
ENSG00000097046 CDC7 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.945663 View
ENSG00000104365 IKBKB ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.945571 View
ENSG00000112062 MAPK14 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.945524 View
ENSG00000126934 MAP2K2 ENSG00000175387 SMAD2 H. sapiens SDL Slorth 0.944935 View
ENSG00000097007 ABL1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.944803 View
ENSG00000101412 E2F1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.944584 View
ENSG00000121022 COPS5 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.94359 View
ENSG00000113558 SKP1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.943548 View
ENSG00000109971 HSPA8 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.940872 View
ENSG00000100811 YY1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.939381 View
ENSG00000126934 MAP2K2 ENSG00000198900 TOP1 H. sapiens SSL Slorth 0.937792 View
ENSG00000091831 ESR1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.937585 View
ENSG00000089157 RPLP0 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.937542 View
ENSG00000010810 FYN ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.936802 View
ENSG00000118689 FOXO3 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.936357 View
ENSG00000004700 RECQL ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.936241 View
ENSG00000124181 PLCG1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.936168 View
ENSG00000010810 FYN ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.934519 View
ENSG00000112062 MAPK14 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.933236 View
ENSG00000096717 SIRT1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.933123 View
ENSG00000100519 PSMC6 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.93223 View
ENSG00000101412 E2F1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.930252 View
ENSG00000108443 RPS6KB1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.929963 View
ENSG00000100644 HIF1A ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.929945 View
ENSG00000102882 MAPK3 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.92978 View
ENSG00000111276 CDKN1B ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.929295 View
ENSG00000126934 MAP2K2 ENSG00000169375 SIN3A H. sapiens SDL Slorth 0.929119 View
ENSG00000124181 PLCG1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.928807 View
ENSG00000055130 CUL1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.928666 View
ENSG00000111276 CDKN1B ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.928163 View
ENSG00000101966 XIAP ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.927359 View
ENSG00000113721 PDGFRB ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.927191 View