MAP2K2

ENSG00000126934 - H. sapiens

Pathways

Go term Description
GO:0004674 protein serine/threonine kinase activity
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0030165 PDZ domain binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0046872 metal ion binding
GO:0097110 scaffold protein binding

Drugs

Drug name Description
TRAMETINIB Dual specificity mitogen-activated protein kinase kinase 2 inhibitor

Diseases

Disease Name
NSCLC
melanoma

Orthologs

Gene Organism
PBS2 S. cerevisiae
mek-2 C. elegans
Dsor1 D. melanogaster

Related Interactions

Gene ID A Gene Name A Gene ID B Gene Symbol B Organism Source Score?
ENSG00000096384 HSP90AB1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.971329 View
ENSG00000126934 MAP2K2 ENSG00000185591 SP1 H. sapiens SDL Slorth 0.970789 View
ENSG00000126934 MAP2K2 ENSG00000132155 RAF1 H. sapiens SDL Slorth 0.970355 View
ENSG00000080824 HSP90AA1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.970015 View
ENSG00000101266 CSNK2A1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.969133 View
ENSG00000104365 IKBKB ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.96902 View
ENSG00000108298 RPL19 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.968611 View
ENSG00000126934 MAP2K2 ENSG00000162385 MAGOH H. sapiens SDL Slorth 0.967863 View
ENSG00000005339 CREBBP ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.967786 View
ENSG00000116030 SUMO1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.966314 View
ENSG00000101843 PSMD10 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.966079 View
ENSG00000100906 NFKBIA ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.965922 View
ENSG00000126934 MAP2K2 ENSG00000146648 EGFR H. sapiens SDL Slorth 0.965903 View
ENSG00000101266 CSNK2A1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.96467 View
ENSG00000103275 UBE2I ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.962723 View
ENSG00000123374 CDK2 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.962667 View
ENSG00000097007 ABL1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.962604 View
ENSG00000122406 RPL5 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.962383 View
ENSG00000112592 TBP ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.961366 View
ENSG00000012048 BRCA1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.960223 View
ENSG00000126934 MAP2K2 ENSG00000166167 BTRC H. sapiens SDL Slorth 0.960011 View
ENSG00000108671 PSMD11 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.958143 View
ENSG00000103035 PSMD7 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.958105 View
ENSG00000069399 BCL3 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.958002 View
ENSG00000101146 RAE1 ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.957987 View
ENSG00000106588 PSMA2 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.95747 View
ENSG00000008018 PSMB1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.957121 View
ENSG00000113575 PPP2CA ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.956948 View
ENSG00000055130 CUL1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.95671 View
ENSG00000126934 MAP2K2 ENSG00000164924 YWHAZ H. sapiens SDL Slorth 0.956466 View
ENSG00000126934 MAP2K2 ENSG00000170312 CDK1 H. sapiens SDL Slorth 0.955915 View
ENSG00000100028 SNRPD3 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.953817 View
ENSG00000112592 TBP ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.953425 View
ENSG00000082701 GSK3B ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.952945 View
ENSG00000126934 MAP2K2 ENSG00000175104 TRAF6 H. sapiens SDL Slorth 0.952392 View
ENSG00000110107 PRPF19 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.951824 View
ENSG00000105372 RPS19 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.951732 View
ENSG00000124762 CDKN1A ENSG00000126934 MAP2K2 H. sapiens SSL Slorth 0.951612 View
ENSG00000126934 MAP2K2 ENSG00000141646 SMAD4 H. sapiens SDL Slorth 0.951494 View
ENSG00000110092 CCND1 ENSG00000126934 MAP2K2 H. sapiens SDL Slorth 0.951022 View