FOXO3 - MAP2K2

SDL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
FOXO3	ENSG00000118689	AL	No drugs in record	core promoter binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding protein kinase binding chromatin DNA binding sequence-specific DNA binding	HCM1 (S. cerevisiae) daf-16 (C. elegans) foxo (D. melanogaster)
MAP2K2	ENSG00000126934	NSCLC melanoma	TRAMETINIB	protein serine/threonine kinase activity signal transducer, downstream of receptor, with serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity protein binding ATP binding PDZ domain binding protein serine/threonine kinase activator activity metal ion binding scaffold protein binding	PBS2 (S. cerevisiae) mek-2 (C. elegans) Dsor1 (D. melanogaster)