DIS3 - TOP1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
DIS3	ENSG00000083520	No diseases in record	No drugs in record	3'-5'-exoribonuclease activity RNA binding endonuclease activity guanyl-nucleotide exchange factor activity protein binding tRNA binding endoribonuclease activity nuclease activity exonuclease activity hydrolase activity nucleic acid binding exoribonuclease activity Ran GTPase binding ribonuclease activity	DIS3 (S. cerevisiae) dis-3 (C. elegans) Dis3 (D. melanogaster)
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)