TCF7L2 - TOP1

SSL interaction

Gene Name	Gene ID	Diseases	Drugs	GO terms	Orthologs
TCF7L2	ENSG00000148737	colorectal	No drugs in record	RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II repressing transcription factor binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding transcription factor binding protein kinase binding nuclear hormone receptor binding sequence-specific DNA binding transcription regulatory region DNA binding gamma-catenin binding armadillo repeat domain binding	pop-1 (C. elegans) pan (D. melanogaster)
TOP1	ENSG00000198900	AML*	IRINOTECAN	core promoter sequence-specific DNA binding DNA binding chromatin binding DNA topoisomerase type I activity protein binding isomerase activity DNA topoisomerase activity	TOP1 (S. cerevisiae) top-1 (C. elegans) Top1 (D. melanogaster)